CAS: 501-29-1; 1-Chloro-2-Fluoro-4-Methoxybenzene

该化合物是一种芳香化合物,其特点是存在氯原子,氟原子和配有苯环的甲氧基(OCH3),该化合物具有一种氯化和氟化芳香系统,可影响其反应性和物理特性.一般而言,它是一种无色的黄色液体或固体,视温度和纯度而定.甲基氧基苯的存在会增加其在有机溶剂中的溶性,并可能影响其电子特性,使其在有机合成和制药中成为有用的中间体.该化合物可能具有中等挥发性,并可能在农用化学中或作为合成更复杂的分子的建筑块中具有特定用途.应当参考安全数据,因为卤化化合物可能构成健康和环境风险.

英文名称1-Chloro-2-Fluoro-4-Methoxybenzene
中文名称4-氯-3-氟苯甲醚
IUPAC名称1-chloro-2-fluoro-4-methoxybenzene
其它别名3-氟-4-氯苯甲醚; 4-Chloro-3-Fluoroanisole
CAS编号501-29-1
MFCD编号:MFCD00042570
EINECS号:610-503-2
分子式:C7H6ClFO
分子量:160.57
产品CID: 1488650
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: FAVMSTGWFRDCRR-UHFFFAOYSA-N
InChI=1S/C7H6ClFO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,1H3…
计算化学: 氢键受体数1.0氢键供体数0可旋转键数1

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号1993
危险品标志Xi
风险等级Irritant
安全声明37/39-26
危险类别码36/37/38

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-fluoro-4-(methoxy)aniline 2-fluoro-4-methoxy-1-nitro-benzene 1-chloro-2,4-difluorobenzene potassium methanolate 1-bromo-5-chloro-4-fluoro-2-methoxybenzene 3-chloro-2-fluoro-6-methoxybenzaldehyde 1-(5-chloro-4-fluoro-2-methoxyphenyl)ethanone 5-(4-fluoro-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)benzofuran-5-yl)-2-methoxy-4-methyl-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide

合成工艺路线路线简述

3-氟-4-硝基苯甲醚置于铁粉,溶剂黄146体系中,化学反应生成 4-氯-3-氟苯甲醚
参考文献:Hodgson; Nixon,Journal Of The Chemical Society,1931,P. 981
标题:Hodgson; Nixon,Journal Of The Chemical Society,1931,P. 981

海关参考信息

2903919090-氯苯
2905110000-甲醇
2908191000-对氯苯酚
2908999090-其他酚的硝化衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9067934-B2
优先权日:2011-03-31
标题 :Bicyclic pyridinones
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.