专利号:US-6693091-B2 优先权日:2002-03-29 标 题 :Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies 发明人:STROMGAARD KRISTIAN; SUEHIRO MAKIKO; NAKANISHI KOJI 权利人:UNIV COLUMBIA 摘要:A compound having the structure: n wherein R 1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 3 is H or OH; n wherein R 4 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and n wherein at least one of R 1 , R 2 , R 3 , or R 4 is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety. Optically pure enantiomers and salts of the compound are also described. Also, the synthesis of the compound, and uses of the compound, such as in a method for detecting the localization of, or identifying, receptors, enzymes or other targets, whether in a cell or in a subject.
专利号:US-9790531-B2 优先权日:2012-08-14 标 题 :Enzymes and polymerases for the synthesis of RNA 发明人:WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN 权利人:MODERNATX INC 摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.
专利号:US-2008087545-A1 优先权日:2003-07-24 标题:Microchemical method and apparatus for synthesis and coating of colloidal nanoparticles 发明人:JENSEN KLAVS F; KHAN SAIF A 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The present invention represents a radical departure from most conventional macro-scale batch processing methods employed to synthesize and coat colloidal nanoparticles. Synthesis and coating are in series and in-situ, obviating the need for numerous cumbersome, and often expensive intermediate-processing steps. In one embodiment, the invention is a method and apparatus for synthesizing colloidal nanoparticles. In another embodiment, the invention is a method and apparatus for enabling coating of colloidal nanoparticles using an electrophoretic switch for contacting and separating said colloid nanoparticles.
专利号:US-2017065721-A1 优先权日:2010-08-04 标题:Synthesis and use of therapeutic metal ion containing polymeric particles 发明人:PETROS ROBBY A 权利人:UNIV NORTH TEXAS 摘要:Therapeutic particles contain metal ions and are characterized by the use of unique ligand sets capable of making the metal ion complex soluble in biological media to induce selective toxicity in diseased cells. The particles may comprise a polymeric base particle, at least one pharmaceutically active metal ion, including metal ions from more than one metal element, a ligand that is covalently attached to the polymeric base particle and attached to the metal ion via a stimuli-responsive bond, and a cell targeting component. When the metal ion-containing particle enters a pre-defined environment, the ligands binding the metal to the particle are broken, triggering release of the free metal ion while the original ligands remain covalently bound to the particle.
专利号:US-11920174-B2 优先权日:2016-03-03 标 题 :RNA analysis by total hydrolysis and quantification of released nucleosides 发明人:EBER FABIAN JOHANNES; WOCHNER ANIELA; ROOS TILMANN 权利人:CureVac SE 摘要:The present invention relates to analysis of an RNA molecule. It further relates to the use of this method for the quality control of an RNA molecule produced by in vitro transcription or for the quality control of an RNA molecule produced by chemical synthesis.
专利号:KR-20220129023-A 优先权日:2020-01-16 标题:Reagents for modular enantiomeric synthesis of C-P bonds and uses thereof
参考文献:10.1007/bf00152688 摘要:Holt PS, Misfeldt L. Biological effects of Pseudomonas aeruginosa exotoxin A: Lymphoproliferation of T lymphocytes in athymic mice. European Journal of Epidemiology. 1988 Mar;4(1):25–32. doi: 10.1007/bf00152688. 参考文献:10.1007/pl00008605 摘要:Phillips RJ, Hickleton DC, Boehmer PE, Emmerson PT. The RecB protein of Escherichia coli translocates along single-stranded DNA in the 3′ to 5′ direction: a proposed ratchet mechanism. Molecular Genetics and Genomics. 1997 Apr;254(3):319–29. doi: 10.1007/pl00008605.