CAS: 4372-67-2; 8-Azido Adenosine

该化合物是一个经过修改的核循环体,在腺基的8个位置上有一个Azido组(-N3),该化合物的特点是能够参与化学反应点击,使其成为生物凝聚和标签研究的宝贵工具;它保留了的纯净结构,允许它与核酸成分互动,但组引入了独特的反应性,可用于各种生物化学应用. 8-Azidoadenosine经常用于研究核酸相互作用,细胞吸收和核细胞模拟作用机制的研究.在生理条件下,其稳定性一般良好,尽管对光和某些化学环境可能很敏感.此外,由于其亚氨功能,它可以用于光化学反应,并作为合成其他生物活性化合物的前体.

结构式图片

MSDS等安全信息

    上下游产品

    CAS号58-61-7 腺苷 | CAS号2946-39-6 8-溴腺苷 | CAS号3868-33-5 8-氨基腺苷酸 | CAS号79270-98-7 8-azidoadenine

    合成工艺路线路线简述

    • 合成目标产物 8-Azidoadenosine 主要起始原料 8-Bromoadenosine
    • (文献来源)合成步骤主要原料 8-Bromoadenosine
    📜腺苷置于sodium Azide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.0H,以74%的收率获得产物8-叠氮酰苷
    参考文献:Sayed Ahmed,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1996,Vol. 35,# 6,P. 595-597
    标题:Sayed Ahmed,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1996,Vol. 35,# 6,P. 595-597

    海关参考信息

    专利信息


    专利号:US-6693091-B2
    优先权日:2002-03-29
    标 题 :Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies
    发明人:STROMGAARD KRISTIAN; SUEHIRO MAKIKO; NAKANISHI KOJI
    权利人:UNIV COLUMBIA
    摘要:A compound having the structure: n wherein R 1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 3 is H or OH; n wherein R 4 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and n wherein at least one of R 1 , R 2 , R 3 , or R 4 is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety. Optically pure enantiomers and salts of the compound are also described. Also, the synthesis of the compound, and uses of the compound, such as in a method for detecting the localization of, or identifying, receptors, enzymes or other targets, whether in a cell or in a subject.

    专利号:US-9790531-B2
    优先权日:2012-08-14
    标 题 :Enzymes and polymerases for the synthesis of RNA
    发明人:WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
    权利人:MODERNATX INC
    摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

    专利号:US-2008087545-A1
    优先权日:2003-07-24
    标题:Microchemical method and apparatus for synthesis and coating of colloidal nanoparticles
    发明人:JENSEN KLAVS F; KHAN SAIF A
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The present invention represents a radical departure from most conventional macro-scale batch processing methods employed to synthesize and coat colloidal nanoparticles. Synthesis and coating are in series and in-situ, obviating the need for numerous cumbersome, and often expensive intermediate-processing steps. In one embodiment, the invention is a method and apparatus for synthesizing colloidal nanoparticles. In another embodiment, the invention is a method and apparatus for enabling coating of colloidal nanoparticles using an electrophoretic switch for contacting and separating said colloid nanoparticles.

    专利号:US-2017065721-A1
    优先权日:2010-08-04
    标题:Synthesis and use of therapeutic metal ion containing polymeric particles
    发明人:PETROS ROBBY A
    权利人:UNIV NORTH TEXAS
    摘要:Therapeutic particles contain metal ions and are characterized by the use of unique ligand sets capable of making the metal ion complex soluble in biological media to induce selective toxicity in diseased cells. The particles may comprise a polymeric base particle, at least one pharmaceutically active metal ion, including metal ions from more than one metal element, a ligand that is covalently attached to the polymeric base particle and attached to the metal ion via a stimuli-responsive bond, and a cell targeting component. When the metal ion-containing particle enters a pre-defined environment, the ligands binding the metal to the particle are broken, triggering release of the free metal ion while the original ligands remain covalently bound to the particle.

    专利号:US-11920174-B2
    优先权日:2016-03-03
    标 题 :RNA analysis by total hydrolysis and quantification of released nucleosides
    发明人:EBER FABIAN JOHANNES; WOCHNER ANIELA; ROOS TILMANN
    权利人:CureVac SE
    摘要:The present invention relates to analysis of an RNA molecule. It further relates to the use of this method for the quality control of an RNA molecule produced by in vitro transcription or for the quality control of an RNA molecule produced by chemical synthesis.

    专利号:KR-20220129023-A
    优先权日:2020-01-16
    标题:Reagents for modular enantiomeric synthesis of C-P bonds and uses thereof

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/bf00152688
    摘要:Holt PS, Misfeldt L. Biological effects of Pseudomonas aeruginosa exotoxin A: Lymphoproliferation of T lymphocytes in athymic mice. European Journal of Epidemiology. 1988 Mar;4(1):25–32. doi: 10.1007/bf00152688.
    参考文献:10.1007/pl00008605
    摘要:Phillips RJ, Hickleton DC, Boehmer PE, Emmerson PT. The RecB protein of Escherichia coli translocates along single-stranded DNA in the 3′ to 5′ direction: a proposed ratchet mechanism. Molecular Genetics and Genomics. 1997 Apr;254(3):319–29. doi: 10.1007/pl00008605.
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