CAS: 4290-13-5; (3As,5Ar,6R,9As,9Bs)-6-Hydroxy-5A,9-Dimethyl-3-Methylene-3A,4,5,5A,6,7,9A,9B-Octahydronaphtho[1,2-B]Furan-2(3H)-One

上下游产品

gallicin costunolide costunolide-1,10-epoxideepoxysantamarin 11,13-dihydrosantamarin

📜在 盐酸,三氟化硼乙醚,间氯过氧苯甲酸体系中,用 氯仿,苯 作为反应溶剂,化学反应 13.0H,反应生成 裂叶苣荚莱内酯
参考文献:绝对立体结构和saussureamines A的合成,B,C,D和e,氨基酸缀合物倍半萜与胃保护作用,从根云木香
标题:绝对立体结构和saussureamines A的合成,B,C,D和e,氨基酸缀合物倍半萜与胃保护作用,从根云木香
摘要:从五味子雪莲干燥根的甲醇提取物中,分离出五种氨基酸-倍半萜烯共轭物,五味子胺a,B,C,D和e,以及木脂糖苷,(-)-Massoniresinol 4"-ø-β-D-吡喃葡萄糖苷.它们的立体结构是根据化学和物理化学证据确定的.此外,使用氨基酸与倍半萜烯的α-亚甲基-γ-内酯部分的迈克尔型加成反应,合成了雪沙胺和相关的氨基酸-倍半萜烯共轭物.索绪尔胺a,B和c,木香内酯和脱氢古木酸内酯对大鼠的酸化乙醇诱导的胃粘膜损伤具有胃保护作用.鼠尾草胺a还对小鼠的水浸应激诱导的胃粘膜损伤表现出抑制作用.
DOI:10.1016/s0040-4020(00)00696-7

专利信息

专利号:US-11565248-B2
优先权日:2017-10-31
标 题:Process for a mild aqueous synthesis of titanium phosphates—ion—exchangers having solely—H2PO4 active groups
发明人：ANTZUTKIN OLEG N; TRUBLET MYLÈNE CLAIRE; RUSANOVA-NAYDENOVA DANIELA PENCHEVA
权利人:ANTZUTKIN OLEG N; TRUBLET MYLENE CLAIRE; RUSANOVA NAYDENOVA DANIELA PENCHEVA
摘要:The invention relates to a process for performing a aqueous synthesis of titanium phosphates (TiP) having solely —H2PO4 groups, which process is characterised by the following steps: providing titanium (IV) oxysulphate, TiOSO4, in an aqueous solution or in a powder and H2SO4, substantially without transition divalent metal ions, including cobalt (II) and copper (II), heating of the thus formed aqueous solution to above 50° C., but below 85° C. for at least 30 minutes, providing a controlled amount of H3PO4 to said aqueous solution, to form an aqueous solution containing a molar ratio between TIO2 and P2Os being controlled to about 1:1, not above 1:1.5 and not below 1:0.7, stirring the thus formed aqueous solution for at least 3 hours to form precipitates of titanium phosphate, and allowing ageing of said solution, without stirring, acidic washing of the formed precipitate using HCI or other acids to obtain TiO(OH)(H2PO4)-H2O having solely —H2PO4 ion-exchange chemical groups and allowing said precipitates to dry to a powder product, substituting protons in the powder product TiO(OH)(H2PO4)-H2O to sodium cations by treatment of the latter with solutions of sodium carbonate and allowing the thus formed powder of Na—TiP1 to dry.

专利号:US-2023109627-A1
优先权日:2019-11-14
标 题:Precursor chemistry for quantum dot synthesis enabling temperature-independent modulation of reactivity
发明人：HAN HEE-SUN; PARK JOONHYUCK
权利人:UNIV ILLINOIS
摘要:Provided herein are methods of making a high-quality quantum dot (QD), including by providing anion precursor chemistry that enables chemical modulation of precursor reactivity, thereby, allowing independent optimization of reaction temperature and precursor reactivity to systematically grow high quality QDs and by providing specially configured tunable precursors and related chemistry to facilitate separate reaction pathways for nucleation and growth, thereby accessing heat-up based synthesis of high-quality QD, including core-shell QDs. The methods may include providing a base-QD and a first anion or cation precursor having a composition comprising an anion or a cation element, respectively, and a modification agent. At least one add-layer is grown on the base-QD at a growth temperature, thereby making the high-quality QD comprising the base-QD and the at least one add-layer. At least one add-layer may have a composition comprising an add-layer cation element and an add-layer anion element.

专利号:US-2023221331-A1
优先权日:2020-01-24
标题:Identification And Synthesis Of Drug Candidates Derived From Human Microbiome Metasecretome Proteins
发明人：CHENE LAURENT; STROZZI FRANCESCO; BONNY CHRISTOPHE
权利人:ENTEROME S A
摘要:The present invention relates to the treatment of diseases relating to proteins of the human microbiome metasecretome and, thus, to microbiome interactions, especially microbiome-host interactions. In particular the present invention relates to a method for identification of secreted peptides and proteins of the human microbiome. The present invention also relates to methods for generating a database of human microbiome metasecretome protein sequences. Furthermore, the present invention relates to a method for preparing a protein of the human microbiome metasecretome as well as to the use of such proteins in medicine.

专利号:WO-2024105271-A1
优先权日:2022-11-17
标 题:Preparation of medium molecular weight heparin
发明人：Bhogal Pervinder; BRACKETT JOHN; RUSHTON GRAHAM
权利人:GLYCOS BIOMEDICAL LTD
摘要:The present invention provides the synthesis of medium molecular weight heparins.

专利号:EP-4619446-A1
优先权日:2022-11-17
标 题 :Preparation of medium molecular weight heparin
发明人：BHOGAL PERVINDER SINGH; BRACKETT JOHN; RUSHTON GRAHAM
权利人:GLYCOS BIOMEDICAL LTD
摘要:The present invention provides the synthesis of medium molecular weight heparins.

专利号:WO-2025106117-A1
优先权日:2023-11-17
标题:Medium molecular weight heparin
发明人：BRACKETT JOHN; Bhogal Pervinder; KELLENBACH EDWIN; DIEP ILONA; RUSHTON GRAHAM
权利人:GLYCOS BIOMEDICAL LTD; BRACKETT JOHN
摘要:The present invention relates to reduced medium molecular weight heparin. The present invention further relates to the treatment of endotheliopathy, particularly reduced medium molecular weight heparin for use in the treatment of endotheliopathy. The present invention also relates to the synthesis of reduced medium molecular weight heparins.