CAS: 42438-89-1; (E)-3-(4-Hydroxystyryl)-5-Methoxyphenol

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CAS号537-42-8 紫檀芪 | CAS号67884-29-1 3-[2-(4-hydroxy...

白藜芦醇3,4'-二乙酸酯置于苄基三乙基氯化铵,Sodium Carbonate体系中,用 甲醇,水,丙酮 作为反应溶剂,化学反应 50.0H,反应生成 松茋
参考文献:白藜芦醇甲氧基衍生物的合成及生物学评价
标题:白藜芦醇甲氧基衍生物的合成及生物学评价
摘要:白藜芦醇是一种天然存在的二苯乙烯,具有许多有益的健康作用.各种研究证明了其多种生物学作用,包括抗氧化,抗炎和抗血小板特性,从而支持其心脏保护,神经保护和抗癌活性的潜力.然而,白藜芦醇的一个显着限制是其生物利用度较弱.为了克服这一挑战,多个研究小组研究了新型白藜芦醇衍生物的合成,以提高生物利用度和药理活性.然而,关于白藜芦醇衍生物对血小板功能影响的数据有限.因此,本研究的目的是合成白藜芦醇甲氧基衍生物并评价其抗血小板和抗增殖活性.利用从健康志愿者获得的富血小板血浆(prp)来评估衍生物抑制血小板激活因子(paf),二磷酸腺苷(adp)和凝血酶受体激活肽(trap)诱导的血小板聚集的能力.此外,还针对 Pc-3 和 Hct116 细胞的增殖评估了衍生物的抗肿瘤活性.结果表明,与原始化合物相比,白藜芦醇的一些甲氧基衍生物表现出相当甚至更好的抗血小板活性.最有效的衍生物是 4'-甲氧基衍生物,它对
DOI:10.3390/molecules28145547

专利信息

专利号:US-2024026314-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
发明人：ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

专利号:EP-4251758-A1
优先权日:2020-11-25
标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:US-8728453-B2
优先权日:2011-02-28
标题 :Combinatorial polymeric compositions for drug delivery
发明人：DASGUPTA FALGUNI
权利人:DASGUPTA FALGUNI; INNOVOTECH LLC
摘要:The present invention is directed towards the synthesis of polymeric drug delivery compositions which would address some of the important and difficult to realize aspects of polymer based drug delivery systems by being, biocompatible, stable, capable of achieving desired drug loading, and safe from accidental release while being non-toxic, easy to fabricate and safe for the environment.

专利号:WO-2022109736-A1
优先权日:2020-11-25
标题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:CA-3202377-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds