CAS: 407623-83-0; Ethyl Isoquinoline-7-Carboxylate

主要参考文献

参考标题: [c]-Fused Bicyclic Proline Derivatives And Their Use For Treating Arthritic Conditions Derives De Proline Bicycliques 20041028Us2003008861A1Lin Linus S [us], Et Al20030109Example 10, Step C Example 11, Step A Example 29, Step C (Starting Material)X2,8Xbergmeier S C Et Al: "Synthesis Of Bicyclic Proline Analogs Using A Formal [3 + 2] Intramolecular Aziridine-Allylsilane Cycloaddition Reaction", Tetrahedron, Elsevier Science Publishers, Amsterdam, Nl, Vol. 55, No. 26, 25 June 1999 (1999-06-25), Pages 8025 - 8038, Xp004168571, Issn: 0040-4020Bergmeier S C Et Alsynthesis Of Bicyclic Proline Analogs Using A Formal [3 + 2] Intramolecular Aziridine-Allylsilane Cycloaddition Reactiontetrahedron, Elsevier Science Publishers, Amsterdam, Nl1999062555260040-40208025803845Scheme 7X2Xdatabase Beilstein Beilstein Institute For Organic Chemistry, Frankfurt-Main, De; Xp002288925, Database Accession No. Brn:388906Beilsteinbeilstein Institute For Organic Chemistry, Frankfurt-Main, Debrn:388906Ax4Xmurayama Et Al, Yakugaku Zasshi, Vol. 85, 1965, Pages 765 - 769Murayama Et Alyakugaku Zasshi196585765769Wo0027808A1Aventis Pharma Gmbh [de]20000518214814211517A1-9Awo03074048A1Warner Lambert Co [us], Et Al2003091235253626Px1-9Pxothman M Et Al: "New Fused Lactones From Indolizinediones Via N-Acyliminium Ions", Tetrahedron, Elsevier Science Publishers, Amsterdam, Nl, Vol. 54, No. 30, 23 July 1998 (1998-07-23), Pages 8737 - 8744, Xp004124041, Issn: 0040-4020Othman M Et Alnew Fused Lactones From Indolizinediones Via N-Acyliminium Ionstetrahedron, Elsevier Science Publishers, Amsterdam, Nl1998072354300040-4020873787443A-Escheme 1X1Xguillerm G Et Al: "Synthesis Of Hydroxylated Pyrrolidines Derivatives As Potential Inhibitors Of Sah/mta Nucleosidase", Tetrahedron Letters, Vol. 28, No. 5, 1987, Pages 535 - 538, Xp002288924Guillerm G Et Alsynthesis Of Hydroxylated Pyrrolidines Derivatives As Potential Inhibitors Of Sah/mta Nucleosidasetetrahedron Letters19872855355384Ascheme 2X1X
摘要:This Invention Relates To A Compound Which Is [c]-Fused Bicyclic Proline Derivative, Or A Pharmaceutically Acceptable Salt Thereof; A Pharmaceutical Composition Comprising The Compound Or The Salt Thereof, And Methods Of Treating Diseases, Including, But Not Limited To, Methods Of Preventing Or Inhibiting Joint Cartilage Damage And Preventing Or Treating Diseases Characterized By Joint Cartilage Damage, Joint Inflammation, Or Joint Pain. The [c]-Fused Bicyclic Proline Derivatives Are Compounds Of Formula I As Described Above. Diseases Characterized By Joint Cartilage Damage Or Joint Pain Include, For Example, Osteoarthritis And Rheumatoid Arthritis. Rheumatoid Arthritis Is Also Characterized By Joint Inflammation. This Invention Also Relates To Methods Of Synthesizing And Preparing The [c]-Fused Bicyclic Proline Derivatives, Or A Pharmaceutically Acceptable Salt Thereof.

合成参考文献

摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 278.