CAS: 36438-97-8; 1-Methyl-1,2,3,4-Tetrahydroquinoxaline

上下游产品

4-甲基-3,4-二氢喹噁啉-2(1H)-酮 4-Methyl-3,4-Dihydroquinoxalin-2(1H)-One 67074-63-9
1,2,3,4-四氢喹喔啉 1,2,3,4-Tetrahydro-Quinoxaline 3476-89-9
2-(2-Amino-N-Methylamino)Ethanol 103763-87-7
3,4-二氢-1H-喹噁啉-2-酮 1,2,3,4-Tetrahydroquinoxalin-2-One 59564-59-9

📜3,4-二氢-1H-喹噁啉-2-酮置于lithium Aluminium Tetrahydride,Sodium Cyanoborohydride,溶剂黄146体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 10.0H,反应生成1-甲基-1,2,3,4-四氢喹喔啉二盐酸盐
参考文献:杂芳基酰胺类衍生物及其作为tgr5激动剂的应用
标题:杂芳基酰胺类衍生物及其作为tgr5激动剂的应用
摘要:本发明属于医药技术领域,具体涉及式(I)所示的杂芳基酰胺类tgr5激动剂化合物,其药学上可接受的盐,其酯,其立体异构体或前药,其中r1,R2,R3,R4,R5,R6,R7,R8,R9,R10,R11,X1,X2,X3和y如说明书中所定义;本发明还涉及这些化合物的制备方法,药物制剂,药物组合物以及这些化合物在制备治疗和/或预防与tgr5活性调节有关的疾病中的用途.

专利信息

专利号:US-4774331-A
优先权日:1986-08-22
标 题:Process for ortho-cyanation of phenols or phenylamines
发明人：ADACHI MAKOTO; MATSUMURA HIROMU; SUGASAWA TSUTOMU
权利人:SHIONOGI & CO
摘要:A process for ortho-cyanation of phenols or phenylamines which comprises reacting a phenyl compound having a hydroxy group or an optionally substituted amino or cyclic amino group, of which the ortho position is vacant, with trichloroacetonitrile, a C1-C5 alkyl thiocyanate or a C6 - C12 aryl thiocyanate in the presence of a boron trihalide and treating the resultant product with an alkali is provided, and said process is useful in the synthesis of intermediates for medicinals or pesticides.

专利号:US-4857645-A
优先权日:1986-11-06
标 题:Process for introducing a thiocarboxylic ester group at the orthoposition of phenols or phenylamines
发明人：MAKOTO ADACHI; MATSUMURA HIROMU; SUGASAWA TSUTOMU
权利人:SHIONOGI & CO
摘要:A process for introducing thiocarboxylic ester at ortho-position of phenols or phenylamines which comprises reacting a phenyl compound having group or optionally substituted amino or cyclic amino group, of which at least one ortho-position is vacant, with C 1 -C 5 alkyl thiocyanate, C 7 -C 13 aralkyl thiocyanate or C 6 -C 12 aryl thiocyanate in the presence of a boron trihalide and hydrolyzing the resultant product under acidic conditions is provided, and said process is useful in the synthesis of medicinals, pesticides and dyes.

专利号:CN-116199675-B
优先权日:2021-11-30
标题 :A class of rhodamine fluorescence quenchers and their synthesis and applications