CAS: 349-96-2; 4-Nitrobenzene-1-Sulfonyl Fluoride

该化合物是有机化合物,其特点是有硝基和全氟辛基磺酰氟功能组,附在苯环上,看上去是灰黄色的固体,以其活性闻名,特别是有机合成中的磺酰胺剂;该化合物通常用于制作全氟辛烷磺酸,并用作各种化学反应的试剂,包括蛋白质和peptides的改变;其磺酰氟组使其成为一种强大的电极,允许其参与核细胞替代反应;此外,4-硝基苯基苯氟化物具有中度毒性,应谨慎处理,因为它可引起皮肤,眼睛和呼吸系统刺激;在实验室环境中与该化合物合作时,适当的安全防范措施,包括使用个人防护设备,至关重要.

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CAS号98-74-8 4-硝基苯磺酰氯 | CAS号6325-93-5 4-硝基苯磺酰胺 | CAS号937-32-6 对硝基苯磺酰氯 | CAS号75-09-2 二氯甲烷 | CAS号98-62-4 4-氨基苯磺酰氟 | CAS号6325-93-5 4-硝基苯磺酰胺

合成工艺路线路线简述

    4-Nitrobenzenediazonium Tetrafluoroborate置于potassium Pyrosulfite,N-氟代双苯磺酰胺体系中,用 二氯甲烷,水,乙腈 用作溶剂,化学反应 4.0H,反应生成对硝基苯甲磺酰氟
    参考文献:可见光介导的芳基砜合成磺酰氟
    标题:可见光介导的芳基砜合成磺酰氟
    摘要:磺酰氟是有机合成中广泛应用的有用基序,包括基于硫 (Vi) 氟化物交换的"点击化学".本文描述了一种由芳基砜合成磺酰氟的可见光介导合成方法.在本研究中,K 2 S 2 O 5和n-氟苯磺酰亚胺 (Nfsi) 分别用作磺酰源和氟化剂,用于可见光介导的芳基砜的氟磺酰化,制备 60-85% 的各种磺酰氟.屈服.该协议是一种合成方法,可在室温下提供有用的磺酰氟结构.
    Doi:10.1002/adsc.202100951

    专利信息


    专利号:CN-114539118-A
    优先权日:2020-11-26
    标题:A new process for the synthesis of N-Boc-4-fluoro-L-proline

    专利号:US-11821032-B2
    优先权日:2018-01-24
    标 题 :DNA sequencing reaction additive
    发明人:ANDRUZZI LUISA; ADEDIRAN JIMMY; PELLETIER TIMOTHY; RICKER AUSTIN; DeLucia Angela; MCNALLY BEN; HEVRONI DONA; Marma Mong Sano; SHERIDAN JOHN ANDREW
    权利人:ISOPLEXIS CORP
    摘要:The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3′-O position capped by a disulfide-based 3′-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

    专利号:WO-2024159284-A1
    优先权日:2023-01-30
    标题 :Nav1.7- and/or nav1.8-inhibiting hydrazides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
    发明人:BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
    权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
    摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting hydrazides. More specifically, the present invention relates to hydrazides comprising formula (I):(I), in which the substituents R1 to R8 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.

    专利号:US-11421264-B2
    优先权日:2015-11-06
    标 题:Thiol-containing cleave reagents and oxidative wash
    发明人:Marma Mong Sano; ANDRUZZI LUISA; MCNALLY BEN; DeLucia Angela; HEVRONI DONA; CARPENTER ELIZABETH; BESEV MAGNUS
    权利人:ISOPLEXIS CORP
    摘要:The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

    专利号:CN-120081740-A
    优先权日:2025-02-28
    标 题 :Synthesis method of 2, 6-naphthalene dicarboxylic acid diester
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    合成参考文献


    摘要:Lai, J.; Thomson, B. J.; Sammis, G. M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 6.
    摘要:Lai, J.; Thomson, B. J.; Sammis, G. M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 2.
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