专利号:CN-114539118-A 优先权日:2020-11-26 标题:A new process for the synthesis of N-Boc-4-fluoro-L-proline
专利号:US-11821032-B2 优先权日:2018-01-24 标 题 :DNA sequencing reaction additive 发明人:ANDRUZZI LUISA; ADEDIRAN JIMMY; PELLETIER TIMOTHY; RICKER AUSTIN; DeLucia Angela; MCNALLY BEN; HEVRONI DONA; Marma Mong Sano; SHERIDAN JOHN ANDREW 权利人:ISOPLEXIS CORP 摘要:The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3′-O position capped by a disulfide-based 3′-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.
专利号:WO-2024159284-A1 优先权日:2023-01-30 标题 :Nav1.7- and/or nav1.8-inhibiting hydrazides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits 发明人:BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA 权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ 摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting hydrazides. More specifically, the present invention relates to hydrazides comprising formula (I):(I), in which the substituents R1 to R8 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.
专利号:US-11421264-B2 优先权日:2015-11-06 标 题:Thiol-containing cleave reagents and oxidative wash 发明人:Marma Mong Sano; ANDRUZZI LUISA; MCNALLY BEN; DeLucia Angela; HEVRONI DONA; CARPENTER ELIZABETH; BESEV MAGNUS 权利人:ISOPLEXIS CORP 摘要:The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.
摘要:Lai, J.; Thomson, B. J.; Sammis, G. M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 6. 摘要:Lai, J.; Thomson, B. J.; Sammis, G. M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 2.