CAS: 3482-14-2; Isoquinolin-8-Ol

相似化合物

2439-04-5 7651-82-3 7651-83-4

上下游产品

isoquinoline 8-methoxyisoquinoline ortho-anisaldehyde 8-chloroisoquinoline 8-aminoisoquinoline

📜8-氯异喹啉置于copper Acetylacetonate,Lithium Hydroxide Monohydrate,1,3-Bis(4-Hydroxy-2,6-Dimethylphenyl)Urea体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应 24.0H,以72%的收率获得产物8-羟基异喹啉
参考文献:8-羟基异喹啉的合成方法
标题:8-羟基异喹啉的合成方法
摘要:8‑羟基异喹啉的合成方法,属于异喹啉类化合物的合成方法领域.包括以下步骤:在二甲基亚砜和水的混合溶液中加入8‑氯异喹啉,乙酰丙酮铜,一水合氢氧化锂和配体1,3‑双(4‑羟基‑2,6‑二甲基苯基)脲;在氮气保护下,将所配反应液边加热边搅拌直至反应完成;待搅拌后的反应液冷却后,用hcl酸化至ph=5;将混合液用乙酸乙酯萃取,萃取后的有机相用饱和食盐水洗涤,经过无水硫酸钠干燥后旋干,粗产品经柱层析分离后制得8‑羟基异喹啉.本发明提供了一种以8‑氯异喹啉为原料,合成路线简洁,工艺选择合理,原料简单易得,操作和后处理方便,总收率高达72%,易于放大,可进行大规模生产的8‑羟基异喹啉的合成方法.

专利信息

专利号:US-5212287-A
优先权日:1988-12-21
标题:Pentapeptide synthesis
发明人：TOLLE JOHN C; GIFFORD WENYING Z; FUNK KENNETH W
权利人:IMMUNETECH PHARMACEUTICALS INC
摘要:A method of synthesizing commercial quantities of the pentapeptide L-aspartyl-L-seryl-L-aspartyl-L-prolyl-L-arginine, and salts or solvates thereof, e.g., the hydrochloride or acetate salt or water solvate, compounds useful in pharmaceutical compositions for the treatment of allergic conditions, is disclosed, as are novel intermediate compounds produced in the course of the synthesis.

专利号:CN-112876470-B
优先权日:2019-11-29
标 题 :A kind of method for the synthesis of non-metallic catalyzed quinazolinone compounds without additives

专利号:US-4215219-A
优先权日:1974-02-08
标 题 :Reagents from phenolic and 8-hydroxyquinolinic aldehyde oximes
发明人：FRIDKIN MATITYAHU; KALIR RAMI; PATCHORNIK AVRAHAM; WARSHAWSKY ABRAHAM
权利人:YEDA RES & DEV
摘要:A process for producing reagents useful in organic synthesis, for removing metal values from solutions thereof, for the capture of aldehydes, of the general formula wherein Z designates a recurring part (CH2-CH-CH2) of a polymeric backbone of a polymer like polystyrene, of a copolymer comprising polystyrene and divinylbenzene, and butadiene, or other copolymers comprising styrene moieties; or wherein Z is the aliphatic moiety of a long-chain aralkyl compound having a terminal aryl group; or wherein Z designates alkyl; corresponding compounds wherein instead of the optionally substituted phenyl group there is present an optionally substituted naphthyl group; wherein n is an integer of from 1 to 15, and wherein Q designates a group selected from: +TR wherein R designates -H, lower alkyl, aryl, which may be substituted and wherein R'' designates -H, alkyl, aryl, halogen, nitro or carboxy, or +TR wherein R is -H, lower alkyl, aryl (which may be substituted), R1 is -H, alkyl, aryl (which may be substituted), R2 is -H, alkyl, aryl or substituted aryl, and wherein Y is -H or a non-interferring substituent, which comprises chemically binding an activated chemical moiety to a group or a corresponding naphthyl-containing group, wherein Z is as defined above, according to the reaction scheme: +TR wherein Q is as defined above, or a functional group which can be converted to such group after the chemical bonding; and X is -Cl or -Br.

专利号:US-4171299-A
优先权日:1975-04-04
标题 :Polypeptide agents for blocking the human allergic response
发明人：HAMBURGER ROBERT N
权利人:UNIV CALIFORNIA
摘要:A group of relatively low molecular weight polypeptides having from 3 to 10 amino acids block the allergic response. These 'blocking' polypeptides have amino acid sequences corresponding to amino acid sequences appearing in the 2nd, 3rd and 4th domains of the epsilon chain of IgE. Specific active 'blocking' polypeptides are disclosed and the synthesis and use thereof are described.

专利号:US-4161522-A
优先权日:1975-04-04
标题:Method for blocking allergic responses
发明人：HAMBURGER ROBERT N
权利人:UNIV CALIFORNIA
摘要:A group of relatively low molecular weight polypeptides having from 3 to 10 amino acids block the allergic response. These 'blocking' polypeptides have amino acid sequences corresponding to amino acid sequences appearing in the 2nd, 3rd and 4th domains of the epsilon chain of IgE. Certain derivatives of such polypeptides also exhibit 'blocking' activity. Specific active 'blocking' polypeptides are disclosed and the synthesis and use thereof are described.

专利号:DE-2504397-A1
优先权日:1974-02-08
标题:POLYMERIC ORGANIC REAGENTS, IN PARTICULAR FOR ORGANIC SYNTHESIS, FOR THE SEPARATION OF METALS, FOR THE EXCHANGE OF IONS AND THE SCAPE OF ALDEHYDE AND THE PROCESS FOR THEIR PRODUCTION