CAS: 31314-38-2; 1-Isopropyl-4,4-Diphenylpiperidin

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合成工艺路线路线简述

    📜3-Benzoyl-4-Phenyl-1-Isopropyl-4-Piperidinol,苯置于三氯化铝体系中,化学反应生成普罗地平
    参考文献:Schaefer; Hackmack; Eistetter,Arzneimittel-Forschung/drug Research,1984,Vol. 34,# 3,P. 233-240
    标题:Schaefer; Hackmack; Eistetter,Arzneimittel-Forschung/drug Research,1984,Vol. 34,# 3,P. 233-240

    海关参考信息

    专利信息


    专利号:US-2011104052-A1
    优先权日:2007-12-03
    标 题 :Methods of synthesis and use of chemospheres
    发明人:BARNETT BRADLEY POWERS; GESCHWIND JEFFREY
    权利人:UNIV JOHNS HOPKINS
    摘要:The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.

    专利号:EP-1877518-A1
    优先权日:2005-04-28
    标题:Synthesis of phenyl-substituted polyfluoroanthenes and the use thereof

    专利号:WO-2006114364-A1
    优先权日:2005-04-28
    标题:Synthesis of phenyl-substituted polyfluoroanthenes and the use thereof

    专利号:US-2007166697-A1
    优先权日:2005-12-30
    标题 :Synthesis and use of cross-linked hydrophilic hollow spheres for encapsulating hydrophilic cargo

    专利号:US-2011207234-A1
    优先权日:2005-12-30
    标 题:Synthesis and Use of Cross-Linked Hydrophilic Hollow Spheres for Encapsulating Hydrophilic Cargo
    发明人:MENCHEN STEVEN M
    权利人:LIFE TECHNOLOGIES CORP
    摘要:Cross-linked hydrophilic nanocapsules and various compositions and methods for their preparation and use are provided.

    专利号:EP-2229147-A2
    优先权日:2007-12-03
    标 题 :Methods of synthesis and use of chemospheres

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    主要参考文献


    1: De Meester I, Belyaev A, Lambeir AM, De Meyer GR, Van Osselaer N, Haemers A, Scharpé S. In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro- diphenyl-phosphonate (Prodipine). Biochem Pharmacol. 1997 Jul 1;54(1):173-9. doi: 10.1016/s0006-2952(97)00149-4. 30(7):1129-34. 92(24):868-71. German. 63(10):1495-500. doi: 10.1097/00007890-199705270-00021. 27(4):357-68. doi: 10.1080/004982597240514. 11(2):76-80. doi: 10.1055/s-0028-1094565.

    合成参考文献


    参考文献:10.1007/bf01249078
    摘要:Russ H, Pindur U, Przuntek H. The interaction of 1-alkyl-4, 4-diphenylpiperidines with the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine receptor binding site. Journal of Neural Transmission. 1986 Sep;65(3-4):157–66. doi: 10.1007/bf01249078.
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