CAS: 27258-32-8; 1-Methyl-1H-Pyrazole-3-Carbaldehyde

相似化合物

25016-20-0 84547-62-6 17827-61-1

上下游产品

CAS号25016-20-0 1-甲基吡唑-3-甲酸 | CAS号84547-60-4 1-甲基-1H-吡唑-3-甲酰氯 | CAS号67751-23-9 4-(二甲氨基)-1,1-二甲... | CAS号60-34-4 甲基肼 | CAS号84547-62-6 (1-甲基-1H-吡唑-3-YL)甲醇

1-甲基-1H-吡唑-3-甲酰氯置于palladium 10% On Activated Carbon 氢气体系中,用 甲苯 用作溶剂,化学反应 8.0H,以63%的收率获得1-甲基-1H-吡唑-3-甲醛
参考文献: 4(Spiropiperidinyl)Methyl Substituted Pyrrolidines As Modulators Of Chemokine Receptor Activity[fr] 4(Spiropiperidinyl)Methyl Pyrrolidines Substituees Servant De Modulateurs De L'Activite Des Recepteurs Des Chimiokines
标题: 4(Spiropiperidinyl)Methyl Substituted Pyrrolidines As Modulators Of Chemokine Receptor Activity[fr] 4(Spiropiperidinyl)Methyl Pyrrolidines Substituees Servant De Modulateurs De L'Activite Des Recepteurs Des Chimiokines
摘要:在环的4位上具有螺环哌啶甲基取代基的3-取代吡咯烷可用作化学因子受体活性调节剂.具体来说,这些化合物可用作化学因子受体ccr-3和/或ccr-5的调节剂.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-9925177-B2
优先权日:2015-01-22
标题:4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

专利号:US-11123337-B2
优先权日:2015-01-22
标题 :4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.