CAS: 266360-63-8; H-D-Phe(3,5-Dif)-Oh

上下游产品

2-acetylamino-2-(3,5-difluoro-benzyl)-malonic acid diethyl ester 1-bromomethyl-3,5-difluoro-benzene (R)-2-Acetylamino-3-(3,5-difluoro-phenyl)-propionic acid 2-acetylamino-3-(3,5-difluoro-phenyl)-propionic acid 2-amino-3-(3,5-difluorophenyl)propanamide 3-(3,5-difluoro-phenyl)-2-oxo-propionic acid (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,5-difluorophenyl)propanoic acid

3,5-二氟溴苄置于盐酸,Sodium Hydroxide,Aspergillus Genus Acylase,Sodium Ethanolate,Sodium Acetate体系中,用 1,4-二氧六环,甲醇,乙醇,对二甲苯,水 用作溶剂,化学反应 60.0H,反应生成3,5-二氟-D-苯基丙氨酸
参考文献:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
标题:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
摘要:A Complete Set Of Difluorophenylalanines In The L-Configuration [l-(F-2)Phe] (Namely,L-(2,3-F-2)Phe,L-(2,4F(2))Phe,L-(2,5-F-2)Phe,L-(2,6-F-2)Phe,L-(3,4-F-2)Phe,L-(3,5-F-2)Phe) Was Prepared And Incorporated Into The Thrombin Receptor-Tethered Ligand Peptide Sfllrnp To Identify The Phenyl Hydrogens Of The Phe-2 Residue Involved In The Ch/pi Receptor Interaction. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4039(99)02191-7

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2019330618-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries