CAS: 26272-86-6; 3-Fluorooxetane

上下游产品

CAS号26438-85-7 3-chloro-2-fluo... | CAS号4161-56-2 3-bromo-2-fluor... | CAS号622-04-8 1,3-二苯氧基-2-丙醇

📜3-氯-2-氟丙烷-1-醇置于碳酸氢钠体系中,用 二乙二醇 用作溶剂,化学反应生成3-氟-1-氧杂环丁烷
参考文献:Boguslavskaya,L.S. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1971,Vol. 7,P. 1382-1387
标题:Boguslavskaya,L.S. Et Al.,Journal Of Organic Chemistry Ussr (English Translation),1971,Vol. 7,P. 1382-1387

专利信息

专利号:WO-2023000636-A1
优先权日:2021-07-20
标题:Method for synthesis of (3-fluorooxetan-3-yl)methyl 4-methylbenzenesulfonate
发明人：LIU YANG; WEI YUANBO; WANG QIUFENG; Xue Duoqing; WU YONG
权利人:ACCELA CHEMBIO CO LTD
摘要:A method for synthesis of (3-fluorooxetan-3-yl)methyl 4-methylbenzenesulfonate. A target product is prepared by using diethyl 2-fluoromalonate as a raw material and by means of a methylolation reaction, a hydroxyl protection reaction, a reduction reaction, an esterification reaction, a deprotection reaction, and a ring closure reaction in six steps. The steps are simple, the operation is easy, the raw material utilization rate and the product yield are high, intermediates are easy to separate, and the method is suitable for industrial scale-up production in terms of process safety, cost, raw material utilization rate, product purity, and the like. The results of embodiments show that the total yield of the reactions in the six steps of the method is 40-60%, and the HPLC purity of the target product (3-fluorooxetan-3-yl)methyl 4-methylbenzenesulfonate is greater than 97%.

专利号:KR-102071095-B1
优先权日:2012-07-03
标 题:Heterocyclic modulators of lipid synthesis

专利号:KR-20150032571-A
优先权日:2012-07-03
标 题:Heterocyclic modulators of lipid synthesis