CAS: 260371-16-2; 4-(4-Fluorobenzoyl)-3-(Hydroxymethyl)Benzonitrile

上下游产品

CAS号82104-74-3 5-氰基苯酞 | CAS号352-13-6 4-氟苯基溴化镁 | CAS号460-00-4 对氟溴苯 | CAS号488787-59-3 (S)-4-[4-(二甲胺基)... | CAS号207680-98-6 4-[(4-fluorophe... | CAS号103146-25-4 4-(4-(二甲基氨基)-1-...

📜5-氰基苯酞,4-氟苯基溴化镁置于水,氯化铵体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成4-(4-氟苯甲酰基)-3-羟甲基 苯甲氰
参考文献: Process For Preparing 5-Substituted-1-(4-Fluorophenyl)-1,3-Dihydroisobenzofurans[fr] Procede De Preparation De 1-(4-Fluorophenyle)-1,3-Dihydroisobenzofuranes Substitues En 5
标题: Process For Preparing 5-Substituted-1-(4-Fluorophenyl)-1,3-Dihydroisobenzofurans[fr] Procede De Preparation De 1-(4-Fluorophenyle)-1,3-Dihydroisobenzofuranes Substitues En 5
摘要:本发明涉及一种制备和分离迄今为止未知的固态硼配合物的方法,该配合物的化学式为(v),当5-取代邻苯二酸酯与4-氟苯基溴化镁的溶液反应后,在钠硼氢化物存在下原位还原和配合形成时得到.这种硼配合物可以方便地过滤以去除结构类似的杂质,并随后在酸性介质中进行环化反应以获得高纯度的5-取代邻苯二酚,这是制造西酞普兰和药用可接受的酸盐的关键起始材料.

专利信息

专利号:US-2008119662-A1
优先权日:2004-02-16
标 题:One Spot Synthesis of Citalopram from 5-Cyanophthalide
发明人：NARAHARI BABU AMBATI; SRINIVAS GOUD VUDDAMARI; GAONKAR SANTOSH LAXMAN; MANJUNATHA SULUR G; KULKARNI ASHOK KRISHNA; KULKARNI MADHARI A
权利人:JUBILANT ORGANOSYS LIMTED
摘要:A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5-cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.

专利号:CH-692298-A5
优先权日:1999-10-25
标 题 :Process for the preparation of intermediates for citalopram synthesis and for the production of escitalopram.