CAS: 20780-77-2; 6-Iodoindoline-2,3-Dione

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📜3-碘苯胺置于盐酸,硫酸,Sodium Sulfate体系中,用 水 用作溶剂,化学反应 3.75H,反应生成6-碘靛红
参考文献: Novel Heterocyclic Derivatives Useful As Shp2 Inhibitors[fr] Nouveaux Dérivés Hétérocycliques Utiles En Tant Qu'Inhibiteurs De Shp2
标题: Novel Heterocyclic Derivatives Useful As Shp2 Inhibitors[fr] Nouveaux Dérivés Hétérocycliques Utiles En Tant Qu'Inhibiteurs De Shp2
摘要:提供了某些吡嗪衍生物(i)作为shp2抑制剂,其化学式如下(i),以及它们的合成和用于治疗shp2介导的疾病.更具体地,提供了有用作为shp2抑制剂的融合杂环衍生物,生产这类化合物的方法以及治疗shp2介导的疾病的方法.

专利信息

专利号:US-10858359-B2
优先权日:2016-06-07
标题 :Heterocyclic ring derivatives useful as SHP2 inhibitors
发明人：MA CUNBO; GAO PANLIANG; CHU JIE; WU XINPING; WEN CHUNWEI; KANG DI; BAI JINLONG; PEI XIAOYAN
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.