CAS: 194798-83-9; 2-(2,4-Difluorophenyl)-1,3-Di(1H-1,2,4-Triazol-1-yl)Propan-2-Yl Dihydrogen Phosphate

上下游产品

福司氟康唑杂质e Dibenzyl 2-(2,4-Difluorophenyl)-1,3-Bis(1H-1,2,4-Triazole-1-yl)-2-Propyl Phosphate 194602-25-0
氟康唑 Fluconazole 86386-73-4

📜2-(2,4-Difluorophenyl)-1,3-Bis(1H-1,2,4-Triazol-1-yl)Propan-2-Yl Phosphate Diammonium Salt置于甲酸体系中,化学反应 1.0H,以98.8%的收率获得磷康唑
参考文献:一种福司氟康唑的制备方法
标题:一种福司氟康唑的制备方法
摘要:本发明提供了一种福司氟康唑的制备方法,包括以下步骤:制备二氯磷酸氟康唑酯:在氮气保护下,控制温度‑10~0°C,向三乙胺的二氯甲烷溶液中缓慢滴加三氯氧磷,滴完后,维持温度‑10~0oc搅拌1小时,缓慢滴加氟康唑的二氯甲烷溶液,Tlc监测反应完成;维持温度‑10~0°C,加入水搅拌30分钟,添加无机碱至水相ph至少为8,静置分层,分出上层水相,有机相内含二氯磷酸氟康唑酯,通过氟康唑‑二氯磷酸氟康唑酯‑氟康唑二苄基磷酸酯‑福司氟康唑铵盐‑福司氟康唑流程制备福司氟康唑,提高收率,可控得制备各中间体,原料可回收重复使用,减少原料浪费与有机废物污染.

专利信息

专利号:US-11944609-B1
优先权日:2023-06-16
标题:Antifungal ionic liquid and Amphotericin B combination
发明人：RATHER SAMI-ULLAH; WANI MOHMMAD YOUNUS; BAMUFLEH HISHAM S; ALHUMADE HESHAM; SAEED USMAN; TAIMOOR AQEEL AHMAD; ALALAYAH WALID M; RATHER IRFAN AHMAD
权利人:KING ABDULAZIZ UNIVERISTY; UNIV KING ABDULAZIZ
摘要:Provided herein are ionic liquids that can be used as antifungal agents alone or in combination with Amphotericin B. Also disclosed are methods of synthesis of the ionic liquids and inhibiting fungal growth and methods of treating fungal infections using the disclosed compounds. The disclosure provides antifungal agents that potentiate the antifungal activity of Amphotericin B, a commonly used antifungal drug that could be used alone or in combination. This combination will help control and combat the infections caused by drug resistant Candida. auris in immunocompromised patients.

专利号:US-2012172336-A2
优先权日:2009-03-19
标 题:Fosfluconazole Derivatives, Synthesis, and Use in Long Acting Formulations
发明人：GONNISSEN YVES; VOORSPOELS JODY
权利人:GONNISSEN YVES; VOORSPOELS JODY; SEPS PHARMA N V
摘要:The invention relates to a compound of formula (1) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R 1 to R 2 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.

专利号:WO-2020123881-A1
优先权日:2018-12-12
标题:Boron containing compounds and their uses
发明人：LIU CHUN YU; ZHOU YASHEEN; YANG STEPHEN; LIU CBUNLIANG; ZHANG YONG-KANG
权利人:BORAGEN INC
摘要:The present disclosure relates to boron-containing compounds, novel combiantions, and novel uses. The disclosure provides novel benzoxaborole compounds, pharmaceutical compositions, and associated methods of use. In particular, modeling suggests the benzoxaborole compounds disclosed herein are useful for inhibiting protein prenylation or ergosterol synthesis in a pathogenic microorganism. The benzoxaborole compounds according to the disclosure are further useful for the treatment of infectious microorganisms including pathogenic fungi and protozoan parasites, such as those that cause malaria.

专利号:RU-2176244-C2
优先权日:1996-02-02
标题:Derivatives of triazole, methods of their synthesis, pharmaceutical composition, method of treatment and prophylaxis of fungal infections, intermediate compound