CAS: 1837-55-4; 3,5-Dichloropyridazine

相似化合物

6082-66-2 14161-11-6 1677-80-1

上下游产品

(Z)-2,4,4,4-tetrachlorobut-2-enal 2,4,4,4-tetrachloro-but-2-enal 5-chloro-3-(4-fluorophenyl)pyridazine 5-chloropyridazin-3-amine N-(5-chloropyridazin-3-yl)-1,1-diphenylmethanimine

5-氯哒嗪-3(2H)-酮置于三氯氧磷体系中,化学反应 3.0H,以67%的收率获得3,5-二氯哒嗪
参考文献: Amino-Heterocycles As Vr-1 Antagonists For Treating Pain[fr] Heterocycles Amines En Tant Qu'Antagonistes Du Recepteur Vanilloide (Vr-1) Pour Le Traitement De La Douleur
标题: Amino-Heterocycles As Vr-1 Antagonists For Treating Pain[fr] Heterocycles Amines En Tant Qu'Antagonistes Du Recepteur Vanilloide (Vr-1) Pour Le Traitement De La Douleur
摘要:本发明提供了一种具有以下结构的化合物(i):其中v代表nr5,O,S,So或s(O)2;W和x分别独立地代表ch或n;Y代表n,Ch或c-Ar2,但至少有一个但不超过两个w,X和y为n;Z代表ch或c-Ar2,但当y为n或ch时,则z为c-Ar2,并进一步规定当y为c-Ar2时,Z为ch;Ar1代表包含一个,两个,三个或四个从氮,氧和硫中选择的杂原子的融合的9或10成员杂双环系统,其中所述环系中的至少一个环是芳香的;Ar2代表选择自苯基,吡啶基,嘧啶基和吡啶嗪基的芳香环,可以是可选地融合和取代的;R1代表卤素,羟基,氧,C1-6烷基,C2-6烯基,C2-6炔基,卤代c1-6烷基,羟基c1-6烷基,C1-6烷氧基,卤代c1-6烷氧基,羟基c1-6烷氧基,C3-7环烷基,C3-7环烷氧基,C3-5环烷基c1-4烷基,氰基,硝基,Sr6,Sor6,So2R6,Cor6,Nr3Cor6,Conr3R4,Nr3So2R6,So2Nr3R4,-(Ch2)M羧基,酯化的-(Ch2)M羧基或-(Ch2)Mnr3R4;R2代表氢,卤素,羟基,C1-6烷基,卤代c1-6烷基,C3-7环烷基,C1-6烷氧基,卤代c1-6烷氧基,未取代的苯基或苯基,其上取代有一个或两个从卤素,C1-6烷基,卤代c1-6烷基,C3-7环烷基,C1-6烷氧基或卤代c1-6烷氧基中选择的基团;R3和r4各自独立地代表氢,C1-6烷基,C2-6烯基,C2-6炔基,C3-7环烷基或氟代c1-6烷基;或r3和r4和它们连接的氮原子共同形成一个由4到7个环原子组成的杂原烷环,可选地取代为一个或两个从羟基或c1-4烷氧基中选择的基团,该环可能可选地包含作为所述环原子之一的氧或硫原子,S(O),S(O)2或nr5;R5代表氢,C1-4烷基,羟基c1-4烷基或c1-4烷氧基c1-4烷基;R6代表氢,C1-6烷基,氟代c1-6烷基,C3-7环烷基,未取代的苯基或苯基,其上取代有一个或两个从卤素,C1-6烷基,卤代c1-6烷基,C3-7环烷基,C1-6烷氧基或卤代c1-6烷氧基中选择的基团;M为零或从1到4的整数;N为零或从1到3的整数;或其药学上可接受的盐,N-氧化物或前药;包含它的药物组合物;其在治疗方法中的用途;用于制造用于治疗vr-1相关病症的药物,例如疼痛和/或炎症占优势的病症的用途;以及使用它的治疗方法.

专利信息

专利号:WO-2024256496-A1
优先权日:2023-06-14
标题 :[1,2,4]-triazolo[4,3-b]pyridazine derivatives useful as a medicament
发明人：ELIE JONATHAN; GEORGE PASCAL; MIEGE FRÉDÉRIC; MEIJER LAURENT
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I) or any of its pharmaceutically acceptable salt. The present invention further relates to a synthesis process for manufacturing compound of formula (I) or any of its pharmaceutically acceptable salts, comprising at least a step of reacting a compound of formula (II) with an amine of formula (IV) NHR5R6 for example in a molar ratio ranging from 1 to 20 eq, with respect to the compound of formula (II), in an aprotic solvent or without solvent or else in a protic solvent.

专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

专利号:WO-2024159288-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting amides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting amides. More specifically, the present invention relates to amides comprising formula (I): (Ia) (Ib), in which the substituents R1 to R27 are selected independently of the groups defined in the description, as well as to processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.

专利号:CN-105254633-A
优先权日:2015-09-29
标 题:Synthesis method of imidazo[1, 2-b]pyridazine-3-carbonitrile