CAS: 17083-23-7; H-Tyr(Tbu)-Otbu.Hcl

该化合物是一种手性氨基酸衍生物,其成分包括乙丁基酯和乙醚保护组,加强了有机合成的稳定性和溶性,其立体特性和保护功能使得它对于铅化联结和制药中间应用具有价值,确保了在复杂的合成途径中有受控的回反应性和高纯度.

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129460-19-1 158008-98-1 18822-59-8

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CAS号1164-16-5 N-苄氧羰基-L-酪氨酸 | CAS号16679-94-0 N-[(苯基甲氧基)羰基]-L... | CAS号4089-07-0 L-酪氨酸乙酯盐酸盐

合成工艺路线路线简述

    📜N-苄氧羰基-L-酪氨酸置于palladium On Activated Charcoal 盐酸,二氯甲烷,硫酸,氢气体系中,用 二氯甲烷 用作溶剂,化学反应 175.0H,反应生成Tbu-酪氨酸叔丁酯盐酸盐
    参考文献:Heinzel,Wolfgang; Kronbach,Thomas; Voelter,Wolfgang,Zeitschrift Fur Naturforschung,Teil B: Anorganische Chemie,Organische Chemie,1982,Vol. 37,# 12,P. 1652-1658
    标题:Heinzel,Wolfgang; Kronbach,Thomas; Voelter,Wolfgang,Zeitschrift Fur Naturforschung,Teil B: Anorganische Chemie,Organische Chemie,1982,Vol. 37,# 12,P. 1652-1658

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    专利信息


    专利号:US-12133900-B2
    优先权日:2013-03-15
    标 题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
    发明人:LOW PHILIP STEWART; KULARATNE SUMITH A; MAHALINGAM SAKKARAPALAYAM M
    权利人:PURDUE RESEARCH FOUNDATION
    摘要:The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds. The disclosure also relates to compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

    专利号:US-5434138-A
    优先权日:1990-08-04
    标 题:Gonadoliberin antagonists
    发明人:KOENIG WOLFGANG; SANDOW JUERGEN; KOLAR CENEK
    权利人:HOECHST AG
    摘要:Peptides of the formula in which X is alkanoyl, A is optionally substituted D-Nal(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser (R1), F is Leu, Trp or Phe, G is L-Ser(R1), H is Gly-NH2, D-Ala-NH2 or Azagly-NH2 and R1 is a glycosyl radical. These peptides have an inhibitory effect on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testo-sterone and estrogen. A process for the preparation of these peptides is described.

    专利号:CH-416667-A
    优先权日:1961-04-20
    标 题:Process for protecting the hydroxyl groups of oxyamino acids or their functional derivatives in the synthesis of peptides

    专利号:US-12053532-B2
    优先权日:2013-03-15
    标题 :Synthesis and composition of non-amino acid linking groups conjugated to compounds used for the targeted imaging of tumors

    专利号:US-2022395588-A1
    优先权日:2013-03-15
    标 题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors

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