CAS: 1331-81-3; 4-Methoxybenzyl Alcohol

专利信息

专利号:US-8383810-B2
优先权日:2004-12-20
标题:Process for the synthesis of azetidinones
发明人：THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L
权利人:MERCK SHARP & DOHME; THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L
摘要:A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl.

专利号:US-2001041803-A1
优先权日:2000-03-21
标题 :Conversion of 9-dihydro-13-acetylbaccatin III to baccatin III and 10-deacetyl baccatin III
发明人：KASITU GERTRUDE C; NOAH JAPHETH W
摘要:Novel methods and synthetic intermediates to prepare baccatin III and 10-deacetylbaccatin from readily available 9-dihydro-13-acetylbaccatin III are described. Selective protection and deprotection of the C-7 hydroxyl functionality provides an entry into facile synthesis of novel taxol intermediates, as well as, providing new methods for the preparation of paclitaxel and docetaxel in large scale. Selective oxidation of the C-9 hydroxyl without the need for protection of the C-7 hydroxyl is described.

专利号:US-4243787-A
优先权日:1977-11-23
标 题 :Bulk anionic polymerization process using an alkali metal amide and the salt of the same alkali metal with a hydroxylic compound
发明人：BOILEAU SYLVIE L; CAUBERE PAUL J; NDEBEKA GILBERTE; LECOLIER SERGE L; RAYNAL SERGE F
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to a process for the anionic polymerization and copolymerization of vinyl, dienic and heterocyclic monomers. According to the invention, the process consists in carrying out the reaction in the presence of an initiator consisting of a molecular combination of an alkali metal amide and the salt of the same alkali metal with at least one hydroxylic compound and in the absence of solvent. The initiator can be prepared by intimately mixing its constituents or in the presence of a solvent of low polarity which is subsequently evaporated off, or in situ in the monomer. Application to the synthesis of special or widely used polymers and copolymers.

专利号:US-2012115907-A1
优先权日:2009-04-24
标题 :Novel compounds as inhibitors of renin
发明人：THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R
权利人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R; CADILA HEALTHCARE LTD
摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

专利号:US-12215121-B2
优先权日:2020-12-29
标 题 :Linker structures with minimal scar for enzymatic synthesis
发明人：NGUYEN BICHLIEN HOANG; SMITH JAKE
权利人:MICROSOFT TECHNOLOGY LICENSING LLC
摘要:This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

专利号:US-9388345-B2
优先权日:2012-07-03
标题:Hydrocarbon synthesis methods, apparatus, and systems
发明人：MCNEFF CLAYTON V; MCNEFF LARRY C; NOWLAN DANIEL THOMAS; YAN BINGWEN; GREUEL PETER G
权利人:SARTEC CORP
摘要:Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a process for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.