CAS: 123696-02-6; 3-Chloro-5-Methoxypyridazine

相似化合物

70952-62-4 1677-81-2 1415928-75-4

上下游产品

CAS号2096-20-0 3,5-二甲氧基哒嗪 | CAS号20733-11-3 4-甲氧基哒嗪

5-Methoxy-2-(Tetrahydro-2H-Pyran-2-yl)-3(2H)-Pyridazinone置于盐酸,三氯氧磷体系中,用 甲醇 用作溶剂,化学反应 2.03H,反应生成3-氯-5-甲氧基哒嗪
参考文献:3-氯-5-甲氧基哒嗪的大规模合成
标题:3-氯-5-甲氧基哒嗪的大规模合成
摘要:开发了一种大规模合成3-氯-5-甲氧基哒嗪(18摩尔)的方法,该方法依赖于保护4,5-二氯-3(2 H)-哒嗪酮作为四氢吡喃基衍生物2的哒嗪酮氮.用甲醇选择性地保护被保护的哒嗪酮的5-氯位置,得到3,然后4-氯的催化氢化,得到4.用酸去除保护基,然后用三氯氧磷处理,得到目标化合物6,屈服.该途径优于先前描述的该化合物的合成.
Doi:10.1002/jhet.5570320510

专利信息

专利号:WO-2024256496-A1
优先权日:2023-06-14
标题 :[1,2,4]-triazolo[4,3-b]pyridazine derivatives useful as a medicament
发明人：ELIE JONATHAN; GEORGE PASCAL; MIEGE FRÉDÉRIC; MEIJER LAURENT
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I) or any of its pharmaceutically acceptable salt. The present invention further relates to a synthesis process for manufacturing compound of formula (I) or any of its pharmaceutically acceptable salts, comprising at least a step of reacting a compound of formula (II) with an amine of formula (IV) NHR5R6 for example in a molar ratio ranging from 1 to 20 eq, with respect to the compound of formula (II), in an aprotic solvent or without solvent or else in a protic solvent.