专利号:WO-2025044766-A1 优先权日:2023-08-31 标题:Use of silicon dioxide microspheres in synthesis of ultra-long oligonucleotide and method for synthesizing ultra-long oligonucleotide 发明人:SHI YONGYONG; ZHANG MANCANG; WANG LIBING; GAO PANPAN; FANG JUN 权利人:UNIV SHANGHAI JIAOTONG; SHANGHAI DYNEGENE TECH CO LTD 摘要:The present invention relates to the technical field of oligonucleotide synthesis. Disclosed are the use of silicon dioxide microspheres in the synthesis of an ultra-long oligonucleotide and a method for synthesizing an ultra-long oligonucleotide, wherein the silicon dioxide microspheres have a specific surface area of less than 1 m2/g, and preferably, the silicon dioxide microspheres have modification groups on the surface. The method for synthesizing an ultra-long oligonucleotide comprises: performing a coupling reaction on a nucleoside phosphoramidite synthesis unit using the silicon dioxide microspheres having modification groups on the surface as carriers under coupling reaction conditions. The prepared carriers can be used to prepare an ultra-long oligonucleotide.
专利号:WO-2023102600-A1 优先权日:2021-12-06 标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom 发明人:ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI 权利人:NEWSOUTH INNOVATIONS PTY LTD 摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.
专利号:EP-2607355-A1 优先权日:2011-12-23 标 题:Synthesis of triazolopyrimidine compounds 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.
专利号:US-9278972-B2 优先权日:2011-12-23 标题 :Synthesis of triazolopyrimidine compounds 发明人:MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.
专利号:WO-2004011474-A1 优先权日:2002-07-31 标题:Universal support media for synthesis of oligomeric compounds 发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K 权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K 摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
专利号:WO-2009117718-A1 优先权日:2008-03-20 标 题:Direct chemical synthesis of rare earth-transition metal alloy magnetic materials 发明人:CHINNASAMY C N; HARRIS VINCENT G 权利人:UNIV NORTHEASTERN; CHINNASAMY C N; HARRIS VINCENT G 摘要:A direct chemical synthesis scheme for the fabrication of isotropic and anisotropic rare earth (RE) -transition metal (TM)- based permanent magnets is disclosed. The method according to the invention permits the synthesis of, e.g., particles, films and coatings with controlled particle sizes, shapes, compositions and dispersion in one reaction process. The resulting particles have desirable hard magnetic properties such as high magnetic saturation induction and coercivity at room temperature.
参考文献:10.1016/j.molcel.2008.02.018 摘要:Lorentzen E, Basquin J, Tomecki R, Dziembowski A, Conti E. Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family. Mol Cell. 2008 Mar 28;29(6):717–28. doi: 10.1016/j.molcel.2008.02.018. 参考文献:10.1021/jm301409f 摘要:Ussing CA, Hansen CP, Petersen JG, Jensen AA, Rohde LAH, Ahring PK, Nielsen EØ, Kastrup JS, Gajhede M, Frølund B, Balle T. Synthesis, Pharmacology, and Biostructural Characterization of Novel α4β2Nicotinic Acetylcholine Receptor Agonists. J. Med. Chem. 2013 Jan 22;56(3):940–51. doi: 10.1021/jm301409f. 参考文献:10.1021/bi301341r 摘要:Holyoak T, Zhang B, Deng J, Tang Q, Prasannan CB, Fenton AW. Energetic coupling between an oxidizable cysteine and the phosphorylatable N-terminus of human liver pyruvate kinase. Biochemistry. 2013 Jan 22;52(3):466–76.