CAS: 10468-17-4; N-(3-Chlorophenyl)Hydroxylamine
该化合物是一种氢氧胺衍生物,其成分为氯代苯组,通常用作有机合成的中间体,其反应性氢氧胺运动能够参与各种转化,包括硝化氢形成和再处理灭化.电脱氯替代成分增强了其在电益酚替代和金属催化混合反应中的效用.该化合物因其在制药和农用化学研究中的作用而特别受到重视,在这种研究中,它作为生物活性分子的前体.高纯度能确保敏感应用的一贯性能.由于某些条件下潜在的不稳定,建议适当处理.建议在一个冷干环境中储存以保持稳定性.
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- 产品信息参考
- InChIKey: CTTWLAMAVFBFAR-UHFFFAOYSA-N
- 1S/C6H6ClNO/c7-5-2-1-3-6(4-5)8-9/h1-4,8-9H
- 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0
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CAS号121-73-3 间氯硝基苯 | CAS号932-78-5 BENZENE, 1-CHLO... | CAS号108-42-9 间氯苯胺 | CAS号67055-91-8 N-(3-chlorophen... | CAS号131303-57-6 N-m-chloropheny... | CAS号51639-70-4 N-(3-chlorophen... | CAS号78181-58-5 N-(3-chlorophen... | CAS号608-27-5 2,3-二氯苯胺 | CAS号932-78-5 BENZENE, 1-CHLO... | CAS号3964-52-1 2-氯-4-氨基苯酚 | CAS号139-24-2 3,3-Dichloroazo... | CAS号10286-77-8 N1-(2,3-DICHLOR... | CAS号6626-75-1 N-(2,5-Dichloro... | CAS号67055-91-8 N-(3-chlorophen... | CAS号88730-34-1 (N-acetyl-3-chl... | CAS号88730-41-0 N-(3-chlorophen... | CAS号51639-70-4 N-(3-chlorophen...合成工艺路线路线简述
- 合成目标产物 N-(3-Chloro-Phenyl)Hydroxylamine 主要起始原料 1-Chloro-3-Nitrobenzene
- (文献来源)合成步骤主要原料 1-Chloro-3-Nitrobenzene
📜3-硝基氯苯置于rhodium Contaminated With Carbon,一水合肼体系中,用 四氢呋喃 用作溶剂,化学反应 3.0H,以67%的收率获得3-氯苯基羟胺
参考文献:An Asymmetric Pericyclic Cascade Approach To 3-Alkyl-3-Aryloxindoles: Generality,Applications And Mechanistic Investigations
标题:An Asymmetric Pericyclic Cascade Approach To 3-Alkyl-3-Aryloxindoles: Generality,Applications And Mechanistic Investigations
摘要:
Doi:10.1039/c4Ob02526A
专利信息
专利号:US-8816095-B2
优先权日:2008-08-15
标题:Na channels, disease, and related assays and compositions
发明人：BROWN MILTON L; GRINDROD SCOTT; WALLS THOMAS H; HANSEN TODD; SUY SIMENG; PAIGE MIKELL A
权利人:BROWN MILTON L; GRINDROD SCOTT; WALLS THOMAS H; HANSEN TODD; SUY SIMENG; PAIGE MIKELL A; UNIV GEORGETOWN
摘要:Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [ 3 H]-Batrachotoxin-B ([ 3 H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.
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📌 第三方产品分析报告
合成参考文献
摘要:Schmidt, A., Science of Synthesis, (2007) 31, 1750.
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