CAS: 921-26-6; N-Dichlorophosphanyl-N-Propan-2-Ylpropan-2-Amine

二异丙胺置于三氯化磷体系中,用 甲苯 作为反应溶剂,化学反应 3.0H,以68%的收率获得产物二氯-N,N-二异丙基亚磷酰胺
参考文献:Ethylene Trimerisation And Tetramerisation Catalysts With Polar-Substituted Diphosphinoamine Ligands
标题:Ethylene Trimerisation And Tetramerisation Catalysts With Polar-Substituted Diphosphinoamine Ligands
摘要:基于铬的催化剂系统与极性取代的二膦胺配体具有选择性,可以选择乙烯的三聚或四聚,具体取决于极性基团在芳环上的位置.
DOI:10.1039/b412432D

专利信息

专利号:US-8193384-B2
优先权日:2005-07-29
标 题 :Polymer-bound phosphitylating reagents for the synthesis of organophosphorus compounds
发明人：PARANG KEYKAVOUS; AHAMDIBENI YOUSEF
权利人:PARANG KEYKAVOUS; AHAMDIBENI YOUSEF; RHODE ISLAND EDUCATION
摘要:The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, β-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups.

专利号:US-2008221303-A1
优先权日:2004-02-18
标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates
发明人：KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

专利号:US-7557096-B2
优先权日:1998-01-09
标题 :Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
发明人：PETTIT GEORGE R; RHODES MONTE R
权利人:UNIV ARIZONA
摘要:Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugs†.

专利号:US-5902878-A
优先权日:1989-05-24
标 题 :Modified phosphoramidite process for the production of modified nucleic acids
发明人：SELIGER HEINZ-HARTMUT; BERNER SIBYLLE; MUEHLEGGER KLAUS; VON DER ELTZ HERBERT; BATZ HANS-GEORG
权利人:BOEHRINGER MANNHEIM GMBH
摘要:The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

专利号:US-12291489-B2
优先权日:2016-07-01
标 题 :Synthesis of nanocomposites and their use in enhancing plant nutrition
发明人：BISWAS PRATIM; RALIYA RAMESH
权利人:BISWAS PRATIM; RALIYA RAMESH; WASHINGTON UNIVERSITY ST LOUIS
摘要:The present disclosure is related to the development of improved fertilizer for precision and sustainable agriculture. A method was developed wherein efficient NPK nanocomposite for plant nutrition was synthesized in a single step using aerosol science and technology concepts. Further a formulation was prepared by addition of ZnO, TiO 2 and other nanoparticles to the NPK nanocomposite. Also, an aerosol based foliar application technique was developed for the precise delivery of nanoparticles to the plants.

专利号:US-8846898-B2
优先权日:2000-10-17
标题:Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge
发明人：DELLINGER DOUGLAS J
权利人:DELLINGER DOUGLAS J; Lieure Cornu LLC
摘要:Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III) n nwherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy, halogen, SH, NH 2 , azide or DL wherein D is O, S or NH and L is a heteroatom-protecting group, unsubstituted hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; B is a nucleobase; and one of R 11 and R 12 is a blocking group and the other is (IV) or (VI)n n nin which W, X, Y, Z, R 1 and n are as defined herein.