CAS: 85006-25-3; Tert-Butyl (Tert-Butoxycarbonyl)Oxycarbamate

相似化合物

58377-44-9 36016-38-3 42989-85-5

二碳酸二叔丁酯置于盐酸羟胺,三乙胺体系中,用 水,Petroleum Ether 作为反应溶剂,以85%的收率获得产物n,O-二叔丁氧羰基-羟胺
参考文献:的简便合成ñ,ø-双(叔丁氧羰基)-羟胺
标题:的简便合成ñ,ø-双(叔丁氧羰基)-羟胺
摘要:N,O-二(叔丁氧羰基)羟胺在从盐酸羟胺和二-85%产率合成叔丁基二碳酸酯在三乙胺的存在下进行.该化学方法很容易,利用了现成的试剂,与以前公开的方法相比,安全性得到了提高.
DOI:10.1016/s0040-4039(00)61592-7

专利信息

专利号:US-8987504-B2
优先权日:2010-06-18
标题 :Aminohydroxylation of alkenes
发明人：MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL
权利人:MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL; VICTORIA LINK LTD
摘要:The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.

专利号:US-2007099915-A1
优先权日:2005-10-07
标题 :Inhibitors of the hiv integrase enzyme
发明人：DRESS KLAUS R; JOHNSON TED W; PLEWE MICHAEL B; TANIS STEVEN P; ZHU HUICHUN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-2009170846-A1
优先权日:2005-10-03
标题 :Inhibitors of the hiv integrase enzyme
发明人：DRESS KLAUS RUPRECHT; PLEWE MICHAEL BRUNO; JOHNSON TED WILLIAM; TANIS STEVEN PAUL; TRAN KHANH TUAN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus “HIVâ€? integrase enzyme. Formula (I).