CAS: 70627-52-0; N-(4-(Benzyloxy)Benzylidene)-4-Fluoroaniline

上下游产品

CAS号100-39-0 溴化苄 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号371-40-4 4-氟苯胺 | CAS号4397-53-9 4-苄氧基苯甲醛 | CAS号163222-32-0 4'-O-苄氧依折麦布 | CAS号163222-33-1 依泽替米贝 | CAS号191330-56-0 依折麦布酮 | CAS号190595-65-4 依折麦布中间体

氯化苄置于potassium Carbonate体系中,用 N,N-二甲基甲酰胺,异丙醇 作为反应溶剂,化学反应生成 4-苄氧基苯亚甲基-4-氟苯胺
参考文献:エゼチミブ及びその中間体の製造方法
标题:エゼチミブ及びその中間体の製造方法
摘要:制造降低胆固醇药物依非司他的制造方法.反应生成中间体(m1)并去除保护基制造依非司他(i)的方法.[r1为苄基等,R2为硅醚保护基等的醚保护基.][选择图]无

专利信息

专利号:US-9518014-B2
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process
发明人：DING KUILING; WANG XIAOMING; WANG ZHENG
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of β-arylamino α-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of β-arylamino α-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.

专利号:US-6096883-A
优先权日:1996-05-31
标 题 :3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
发明人：WU GEORGE G; CHEN XING; WONG YEE-SHING; SCHUMACHER DORIS P; STEINMAN MARTIN
权利人:SCHERING CORP
摘要:The invention relates to intermediates of the formulae ##STR1## said intermediates being useful in a process for producing a compound of the formula ##STR2## wherein Bn is benzyl and R 1 , 2 and R 3 are as defined in the specification,

专利号:US-9040688-B2
优先权日:2009-03-31
标 题 :Intermediates in the preparation of 1,4-diphenyl azetidinone
发明人：SRIVASTAVA DHANANJAI; SHAKYA RAJIV KUMAR; CHAUDHARI NAMRATA ANIL; ANSARI INAMUS SAQLAIN; SINGH GIRIJ PAL
权利人:SRIVASTAVA DHANANJAI; SHAKYA RAJIV KUMAR; CHAUDHARI NAMRATA ANIL; ANSARI INAMUS SAQLAIN; SINGH GIRIJ PAL; LUPIN LTD
摘要:The process of the present invention relates to a method for the synthesis of a 1,4-diphenylazetidinone of formula (VIII) by using novel oxime intermediates.

专利号:WO-2012173504-A2
优先权日:2011-06-15
标 题 :Method for synthesis of the substituted azetidinones and intermediates for their synthesis

专利号:US-2010168414-A1
优先权日:2006-03-29
标题 :Processes for preparing ezetimibe and intermediate compounds useful for the preparation thereof
发明人：ESCUDE ANA GAVALDA; BOSCH I LLADO JORDI; NETTEKOVEN ULRIKE
权利人:MEDICHEM SA
摘要:The invention relates, in general, to an improved process for converting compounds of Formula II (below) to compounds of Formula III (below), which are key intermediates for the synthesis of ezetimibe, or to ezetimibe itself, wherein in Formulas II and III, R represents hydrogen, alkyl, or a hydroxyl protecting group (e.g., benzyl group, a substituted benzyl group, or a silyl group). The invention further includes the use of the described process and the use of compounds of Formula III made by the described process for the preparation of ezetimibe.

专利号:CA-2731924-A1
优先权日:2008-07-30
标 题 :Process for the synthesis of ezetimibe and intermediates useful therefor