CAS: 700-38-9; 5-Methyl-2-Nitrophenol

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CAS号108-39-4 间甲酚 | CAS号2835-98-5 2-氨基-5-甲基苯酚 | CAS号24542-06-1 5-methyl-2-nitr... | CAS号89586-13-0 methyl 2-acetyl... | CAS号62351-45-5 4-hydroxy-2-met... | CAS号591-09-3 nitro acetate | CAS号89586-12-9 methyl 2-hydrox... | CAS号89-83-8 麝香草酚 | CAS号50-85-1 4-甲基水杨酸 | CAS号4920-77-8 2-硝基间甲酚 | CAS号102871-93-2 2-ethoxy-4-meth... | CAS号39538-68-6 2-甲氧基-4-甲基苯胺 | CAS号5081-36-7 3-甲氧基-4-硝基苯甲酸 | CAS号39549-27-4 6-硝基-2,4-二氯-3-甲基苯酚 | CAS号38512-82-2 5-甲基-2-硝基苯甲醚 | CAS号452-86-8 4-甲基邻苯二酚 | CAS号4619-74-3 2,4,6-三溴-3-甲基苯酚 | CAS号220985-61-5 2-(苄氧基)-4-甲基苯胺 | CAS号18087-10-0 Phenol,4,5-dime... | CAS号23145-65-5 4-溴甲基-2-甲氧基-1-硝基苯

间甲酚置于三聚氯氰,Zinc(II) Nitrate Hexahydrate体系中,用 乙腈 作为反应溶剂,化学反应 0.5H,以65%的收率获得产物6-硝基间甲酚
参考文献:Zn(no 3)2 .6H2O / 2,4,6-三氯-1,3,5-三嗪(tct)硝化酚的温和选择性体系
标题:Zn(no 3)2 .6H2O / 2,4,6-三氯-1,3,5-三嗪(tct)硝化酚的温和选择性体系
摘要:在室温和短反应时间下,以乙腈作为反应溶剂,以zn(no 3)2 .6H2O / Tct对部分酚和萘进行区域选择性硝化.反应条件温和.tct是一种便宜且可商购的试剂.在该转化中,其作为酸催化剂发挥作用.
DOI:10.1016/j.Cclet.2009.11.017

专利信息

专利号:US-4764263-A
优先权日:1987-05-18
标 题:Electrochemical synthesis of substituted aromatic amines in basic media
发明人：GREGORY THOMAS D; STUTTS KENNETH J
权利人:DOW CHEMICAL CO
摘要:Substituted amino aromatic compounds such as 3-amino-4-hydroxybenzoic acid are prepared by electrolytically reducing the corresponding nitro aromatic compound in a basic medium at temperatures below 60° C. and current densities greater than 50 milliamps per square centimeter. The aminohydroxybenzoic acids are useful in the preparation of polybenzoxazoles which are used to make fibers and composites having high strength and thermal stability.

专利号:WO-9729091-A1
优先权日:1996-02-09
标题:Balanol analogues
发明人：NIELSEN JOHN; LYNGSOE LARS OLE
权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE
摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.

专利号:US-4603209-A
优先权日:1984-09-07
标题 :Fluorescent indicator dyes for calcium ions
发明人：TSIEN ROGER Y; GRYNKIEWICZ GRZEGORZ
权利人:UNIV CALIFORNIA
摘要:The present invention discloses a new class of highly fluorescent indicator dyes that are specific for calcium ions. The new fluorescent indicator dyes combine a stilbene-type fluorophore with a tetracarboxylate parent Ca 2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of EGTA and BAPTA. Preferred forms contain extra heterocyclic bridges to reinforce the ethylenic bond of the stilbene and to reduce hydrophobicity. Compared to their widely used predecessor, 'quin2', the new dyes offer up to thirty-fold brighter fluorescence, major changes in wavelength (not just intensity) upon Ca 2+ binding, slightly lower affinities for Ca 2+ , slightly longer wavelengths of excitation, and considerably improved selectivity for Ca 2+ over other divalent cations. These properties, particularly the wavelength sensitivity to Ca 2+ , make the dyes useful indicators for many intracellular applications, especially in single cells, adherent cell layers, or bulk tissues. n The present invention also discloses an improved method for synthesizing alpha-acyloxyalkyl bromides wherein the bromides so synthesized are free of contaminating bis(1-bromoalkyl)ether. The improved method is exemplified herein in the synthesis of acetoxymethyl bromide, a compound useful in preparing the acetoxymethyl esters disclosed herein as novel Ca 2+ specific fluorescent indicators.

专利号:WO-8809398-A1
优先权日:1987-05-18
标 题:Electrochemical synthesis of substituted amines in basic media

专利号:EP-0291865-A2
优先权日:1987-05-18
标 题:Electrochemical synthesis of substituted aromatic amines in basic media

专利号:FI-86563-C
优先权日:1987-05-18
标题:Electrochemical synthesis of substituted amines in basic media