CAS: 698-63-5; 5-Nitrofuran-2-Carbaldehyde

相似化合物

645-12-5 1874-23-3 2493-04-1

上下游产品

(5-nitrofuran-2-yl)methanol 2-(iodomethyl)-5-nitrofuran chloroform 5-nitro-2-furfuraldehyde diacetate 5-nitro-2-acetylfuran furazolidone 3-(5-nitro-furfurylidenamino)-thiazolidin-2-one -2-imidazolidinon1-(5-Nitrofurfuryliden)amino-2-imidazolidinon

糠醛置于硫酸,硝酸,乙酸酐体系中,用 水 作为反应溶剂,化学反应 1.08H,反应生成 5-硝基糠醛
参考文献:基于bnim和radamide支架的葡萄糖调节蛋白94选择性抑制剂的开发.
标题:基于bnim和radamide支架的葡萄糖调节蛋白94选择性抑制剂的开发.
摘要:葡萄糖调节蛋白94(grp94)是分子伴侣蛋白的热休克蛋白90 Kda(hsp90)家族的内质网居民.grp94与许多参与细胞黏附和信号传导的蛋白质相关,包括整联蛋白,Toll样受体,免疫球蛋白和突变型myocilin.grp94被认为是包括青光眼,癌症转移和多发性骨髓瘤在内的多个治疗领域的靶标.虽然与其他hsp90同工型具有85%的相同性,但grp94的n末端atp结合位点具有一个独特的疏水性口袋,该口袋用于设计同工型选择性抑制剂.合并顺式-酰胺生物甾体进入radamide支架导致了最初的grp94选择性抑制剂bnim的开发.现在已经对bnim的芳基侧链进行了结构-活性关系研究,从而得到了改进的类似物,对grp94表现出了更好的效价和选择性.与bnim相比,这些类似物在转移模型中还表现出优异的抗迁移活性,并且在青光眼模型中还表现出增强的突变型肌球蛋白降解.
DOI:10.1021/acs.Jmedchem.6B00085

专利信息

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-9284306-B2
优先权日:2012-05-11
标题 :(R)-Nifuratel, its use for the treatment of infections and synthesis of (R) and (S)-Nifuratel
发明人：GAGLIARDI STEFANIA; CONSONNI ALESSANDRA; MAILLAND FEDERICO; BULGHERONI ANNA
权利人:POLICHEM SA
摘要:(R)-Nifuratel is disclosed together with its use as bactericide and bacteriostatic agent as well as the pharmaceutical compositions containing the same; (R)-nifuratel has been surprisingly found to possess a better antimicrobial profile than either nifuratel racemate or (S)-nifuratel. A new procedure for the synthesis of both (R)-Nifuratel and (S)-Nifuratel is also disclosed.

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

专利号:US-9949970-B2
优先权日:2010-09-14
标题 :Synthesis of new benzothiazole derivatives as potential anti-tubercular agents
发明人：KAMAL AHMED; SHETTI RAJESH VCRNC; SWAPNA PONNAMPALLI; AZEEZA SHAIK; REDDY A MALLA; KHAN INSHAD ALI; ABDULLAH SHEIKH TASDUQ; SHARMA SANDEEP; KALIA NITIN PAL
权利人:COUNCIL SCIENT IND RES
摘要:Disclosed are compounds of general formula A useful as potential anti-tubercular agents. The general formula A is

专利号:EP-0043598-B1
优先权日:1980-07-09
标 题:Process for the transformation of furfural or 5-nitro-furfural into furonitrile or 5-nitro-furonitrile
摘要:1. Process for the transformation of furfural or 5-nitro-furfural into furonitrile or 5-nitro-furonitrile, in which furfural or 5-nitro-furfural is brought into contact with a hydroxylamine salt, characterized in that the synthesis of furonitrile or 5-nitro-furonitrile is achieved in a single step, by bringing the furfural or 5-nitro-furfural into contact with the hydroxylamine salt in N-methyl pyrrolidone (N.M.P.), the mixed substances being taken to a temperature of between 120 degreees C and 165 degrees C.

专利号:US-9220714-B2
优先权日:2006-03-16
标 题 :Nitrofuran compounds for the treatment of cancer and angiogenesis
发明人：SAULNIER SHOLLER GISELLE L; SWAMY NARASIMHA; KALKUNTE STAYAN; SINGH RAKESH K; BRARD LAURENT; KIM KYU KWANG
权利人:WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND; UNIV BROWN; WOMEN AND INFANTS HOSPITAL RHODE ISLAND
摘要:The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.