CAS: 6921-22-8; 2,3-Difluoronitrobenzene

该化合物是一种含分子式C6H3F2NO2的氟化硝基化合物,其特点是,在苯环上存在两个氟原子和一个硝基化合物,具有独特的反应性和电子特性;它是有机合成的宝贵中间体,特别是在制药,农用化学品和特殊材料的制作方面;氟化物替代体在随后的反应中增强了稳定性和影响再生选择性,而硝基体组则为进一步的功能化提供了多种功能性;其明确界定的结构和可预测的再生性使它成为医学和材料化学研究人员的一个有用建筑块;由于具有潜在的毒性和再生性,需要妥善处理.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2,3-difluoroanilline 2,3,4-trifluoronitrobenzene triethylsilane 2-(2-fluoro-6-nitrophenyl)malonic acid dimethyl ester 2-fluoro-N-methyl-6-nitroaniline (2-fluoro-6-nitrophenylamino)acetic acid ethyl ester 2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-imidazol-1-yl-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

合成工艺路线路线简述

  • 合成目标产物 2,3-Difluoronitrobenzene 主要起始原料 2,3-Difluoroaniline
  • (文献来源)合成步骤主要原料 2,3-Difluoroaniline
2,3-二氟苯胺置于tetrafluoroboric Acid,Sodium Nitrite,铜体系中,用 水 作为反应溶剂,化学反应 2.66H,以25%的收率获得产物2,3-二氟硝基苯
参考文献: Heterocyclic Condensed Compounds Useful As Antidiuretic Agents[fr] Composes Condenses Heterocycliques Utilises En Tant Qu'Antidiuretiques
标题: Heterocyclic Condensed Compounds Useful As Antidiuretic Agents[fr] Composes Condenses Heterocycliques Utilises En Tant Qu'Antidiuretiques
摘要:这项发明涉及通式1中的化合物,其中g1是胺基.根据该发明的化合物是抗利尿激素v2受体激动剂.这些化合物的药物组合物可用作抗利尿剂.

专利信息


专利号:UA-47128-U
优先权日:2009-11-10
标 题:METHOD FOR SYNTHESIS OF ISOMERS OF FLUORNITROBENZENESULFONYL CHLORIDE

专利号:US-6956040-B2
优先权日:2001-07-16
标题:Oxazolidinone piperazinyl derivatives as potential antimicrobials
发明人:MEHTA ANITA; ARORA SUDERSHAN K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
权利人:RANBAXY LAB LTD
摘要:The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I n n nwith the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:JP-2006505658-A
优先权日:2002-11-05
标 题:Process for the synthesis of polydimethylketene by Friedel-Crafts cationic polymerization of dimethylketene

专利号:US-7105615-B2
优先权日:2002-11-05
标题:Synthesis method for polydimethylketene by friedel-craft cationic polymerization of dimethylketene
发明人:LINEMANN REINHARD; LE GUILLAUME
权利人:ARKEMA FRANCE
摘要:The invention concerns a cationic catalyst system comprising an initiator (I), a catalyst (K) and a cocatalyst (CoK). The cocatalyst (CoK) is an agent releasing the active polymerizing center of its counter anion generated by the reaction between the catalyst (K) and the initiator (I). Said cocatalyst is characterized by the existence of a double bond electron-depleted by an electroattractive group. It is selected, for example, from the group consisting of the following complexing agents including o-chloranyl (3,4,5,6-tetrachloro-1,2-benzoquinone), p-chloranyl (2,3,5,6-tetrachloro-1,4-benzoquinone), nitrobenzene, trinitrobenzene, or tetracyanoethylene.

专利号:US-6734307-B2
优先权日:2000-07-17
标 题:Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; SUDERSHAN ARORA K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
权利人:RANBAXY LAB LTD
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:WO-2004069816-A1
优先权日:2003-02-07
标 题:Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMAN; YADAV AJAY SINGH; RATTAN ASHOK
权利人:RANBAXY LAB LTD; MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMAN; YADAV AJAY SINGH; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones of the formula h wherein T is a ring and to the processes for the synthesis of the same. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bactericides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
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合成参考文献


参考文献:10.1134/s0022476625050154
摘要:Vaganova TA, Gatilov YV, Kryuchkova NA, Pishchur DP, Malykhin EV. Competition Between Intermolecular Interactions in the Self-Assembly of Cocrystals of Polyfluorinated Arylenediamines with Crown Ethers: Effect of the Cyano Group. J Struct Chem. 2025 May;66(5):1014–34. doi: 10.1134/s0022476625050154.
参考文献:10.1007/s10562-025-05059-9
摘要:Hota NP, Diksha S, Karthikeyan N, Seenu P, Iyer SK. Amino Acid-Assisted Carbon Quantum Dots for Bioimaging, Picric Acid Detection, Antibacterial Activity, and Prefabrication of Pd Nanoparticles as a Potent Nanocatalyst for Coupling Reactions and Reduction of Nitrophenols. Catal Lett. 2025 Jun 03;155(7). doi: 10.1007/s10562-025-05059-9.
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