CAS: 684220-30-2; 4,6-Dichloropyrimidine-2-Carboxylic Acid

相似化合物

811450-22-3 1451391-83-5 811450-17-6

上下游产品

4,6-dichloropyrimidin-2-carboxaldehyde 4-amino-6-chloropyrimidine-2-carboxylic acid methyl 4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxylate (S)-methyl 4-(4-(4-fluorophenoxy)phenyl)-6-(( 1-methoxy-1-oxopropan-2-yl)amino)pyrimidine-2-carboxylate (S)-4-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

📜4,6-二氯-2-嘧啶甲醛置于potassium Permanganate体系中,用 水,丙酮 作为反应溶剂,化学反应 0.75H,反应生成 4,6-二氯-2-嘧啶羧酸
参考文献:Pyrimidine Derivatives As Il-8 Receptor Antagonists
标题:Pyrimidine Derivatives As Il-8 Receptor Antagonists
摘要:含有嘧啶核的化合物及其用于治疗与不适当的白细胞介素-8受体活性相关的疾病和症状的用途已被披露.这些化合物的结构式为i 1 在这些化合物中,Q最好是未取代或取代的杂环烷基;u通常是氢或氟;v最好是氢,卤素,烷基,-o-烷基或-s-烷基.一个代表性的例子是: 2

专利信息

专利号:US-2017327504-A1
优先权日:2014-10-30
标 题:Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
发明人：ROSE CHRISTOPHER; SILBERGER HERBERT; SCHREINER ERWIN; FELZMANN WOLFGANG; MARAS NENAD
权利人:SANDOZ AG
摘要:The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula (I), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.

专利号:WO-2014074883-A1
优先权日:2012-11-08
标题 :Novel synthesis of ld101
发明人：THOMPSON ANDREW S; CHENG HUA
权利人:LYNDOR BIOSCIENCES L L C
摘要:Novel synthetic methods for preparation of LD101, a compound according to formula (A) are disclosed.

专利号:CA-2965558-A1
优先权日:2014-10-30
标题 :Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines

专利号:EP-3212624-A1
优先权日:2014-10-30
标 题 :Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines

专利号:WO-2016066673-A1
优先权日:2014-10-30
标 题 :Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines