CAS: 66584-72-3; (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Cchloro-14-Hydroxy-85,14-Dimethoxy-33,2,7,10-Tetramethyl-12,6-Dioxo-7-Aza-1(6,4)-Oxazinana-3(2,3)-Oxirana-8(1,3)-Benzenacyclotetradecaphane-10,12-Dien-4-Yl Isobutyrate

上下游产品

CAS号78760-20-0 3-maytansinone ... | CAS号57103-68-1 美登醇 | CAS号75340-68-0 (-)-maytansinol | CAS号57103-68-1 美登醇

异丁酸酐置于lithium Hexamethyldisilazane体系中,用 四氢呋喃,乙二醇二甲醚 作为反应溶剂,化学反应 4.75H,反应生成 安丝菌素 P 3
参考文献:Method For The Preparation Of Maytansinoid Esters
标题:Method For The Preparation Of Maytansinoid Esters
摘要:描述了用于制备和纯化美坦西酯类化合物的改进过程,特别是含有硫醇和二硫键的美坦西酯类化合物.在一个方面,该过程包括制备美坦西酯类化合物的过程,其中包括形成美坦西醇或带有游离c-3羟基的美坦西酯类化合物的阴离子,并将该阴离子与活化的羧基化合物反应,从而产生美坦西酯类化合物.

专利信息

专利号:US-10029014-B2
优先权日:2013-09-10
标题:Synthesis of novel asymmetric bow-tie PAMAM dendrimer-based conjugates for tumor-targeting drug delivery
发明人：OJIMA IWAO; WANG TAO; TENG YU-HAN
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present disclosure relates to a dendrimer-based conjugate of the formula V m -D-C-D′-(T-F) n , which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.

专利号:US-2016220688-A1
优先权日:2013-09-10
标题:Synthesis of novel asymmetric bow-tie pamam dendrimer-based conjugates for tumor-targeting drug delivery