CAS: 65043-22-3; 2-(((1H-Inden-7-yl)Oxy)Methyl)Morpholine Hydrochloride

该化合物是一种合成有机化合物,其形态与通过醚桥产生的硝化物衍生物相关联,盐的形成增强了其稳定性和溶性.这一结构表明药用化学的潜在用途,特别是作为生物活性分子的中间体或作为催化剂系统中的离子体.芯可产生芳香相互作用,而单体细胞组则具有极度和氢燃烧能力.盐形式的盐能确保改善处理和储存特性.其精确应用取决于进一步的功能化或特定目标研究,但其模块设计允许在制药或化学研究环境中的多功能.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号60929-60-4 4-morpholin-2-y... | CAS号64966-73-0 (+/-)-2-[(1-hyd... | CAS号926-39-6 2-氨基乙醇硫酸氢酯 | CAS号30190-85-3 1-(inden-7-ylox... | CAS号40987-24-4 (4-苄基吗啉-2-基)甲醇 | CAS号60929-58-0 (+/-)-2-[(1-oxo... | CAS号103003-01-6 2-羟甲基吗啉 | CAS号60929-57-9 2-(p-toluenesul...

合成工艺路线路线简述

    📜(4-苄基吗啉-2-基)甲醇置于palladium On Activated Charcoal 吡啶,盐酸,Lithium Aluminium Tetrahydride,氢气,三乙胺体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 62.0H,反应生成 盐酸茚洛秦
    参考文献:Syntheses Of (.+-.)-2-((Inden-7-Yloxy)Methyl)Morpholine Hydrochloride (Ym-08054,Indeloxazine Hydrochloride) And Its Derivatives With Potential Cerebral-Activating And Antidepressive Properties.
    标题:Syntheses Of (.+-.)-2-((Inden-7-Yloxy)Methyl)Morpholine Hydrochloride (Ym-08054,Indeloxazine Hydrochloride) And Its Derivatives With Potential Cerebral-Activating And Antidepressive Properties.
    摘要:研究了(+/-)-2-[(茚-7-基氧基)甲基]吗啉盐酸盐(7.hcl,Ym-08054,盐酸吲哚嗪)的合成及其光学拆分为左旋和右旋异构体.采用优先结晶法从7.hcl及其互变异构体(+/-)-2-[(茚-4-基氧基)-甲基]吗啉盐酸盐(6.hcl)的平衡混合物中优先结晶,建立了7.hcl的实用合成方法.,在催化量的碱的存在下,在meoh中.研究发现,7.hcl 及其左旋异构体 ((-)-7.hcl) 不仅具有很强的抗抑郁活性,而且具有强大的脑激活特性.还简要讨论了相关化合物的合成和药理活性.
    DOI:10.1248/cpb.33.3766

    海关参考信息

    专利信息


    专利号:ZA-200502624-B
    优先权日:2002-10-30
    标题 :Method for the synthesis of a bifunctional complex.

    专利号:JP-2007520493-A
    优先权日:2004-02-03
    标 题 :Synthesis of cyanoiminobenzimidazole

    专利号:US-1701478-A
    优先权日:1926-02-18
    标 题 :Method of producing ammonia by synthesis of its elements
    发明人：DE JAHN FREDRIK W
    权利人:ATMOSPHERIC NITROGEN CORP

    专利号:US-2628970-A
    优先权日:1950-07-07
    标 题:Synthesis of liquid hydrocarbons
    发明人：ARNOLD JOHN H; GROSSELFINGER FREDERICK B
    权利人:HYDROCARBON RESEARCH INC

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Murai N, Fushiki H, Honda S, Murakami Y, Iwashita A, Irie M, Tamura S, Nagakura Y, Aoki T. Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. Neuroscience. 2015 Mar 19;289:262-9. doi: 10.1016/j.neuroscience.2014.12.065. Epub 2015 Jan 13. doi: 10.1179/1743132815Y.0000000007. Epub 2015 Jan 16. doi: 10.1016/j.ejphar.2014.03.038. Epub 2014 Apr 1. doi: 10.1124/jpet.113.208686. Epub 2013 Dec 12. doi: 10.1016/j.neuropharm.2013.10.030. Epub 2013 Nov 6. Japanese.

    合成参考文献


    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 238(81), 1979 []
    摘要:United States Patent Document., #4297356
    参考文献:10.1023/a:1020953913490
    摘要:Miyazaki I, Iwata-Ichikawa E, Asanuma M, Iida M, Ogawa N. Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line. Neurochem Res. 1999 Jul;24(7):857–60. doi: 10.1023/a:1020953913490.
    参考文献:10.1023/a:1027369119224
    摘要:Kabuto H, Asanuma M, Nishibayashi S, Iida M, Ogawa N. Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil. Neurochem Res. 1997 Jan;22(1):33–6. doi: 10.1023/a:1027369119224.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知