📜(4-(Hexyloxy)Phenyl)Methanol置于2,2,6,6-Tetramethyl-Piperidine-N-Oxyl,Sodium Hypochlorite,碳酸氢钠,Sodium Bromide体系中,用 水,乙酸乙酯,甲苯 作为反应溶剂,化学反应生成 4-正己氧基苯甲醛 参考文献:Synthesis Of Polyfluoro Ketones For Selective Inhibition Of Human Phospholipase A2 Enzymes 标题:Synthesis Of Polyfluoro Ketones For Selective Inhibition Of Human Phospholipase A2 Enzymes 摘要:The Development Of Selective Inhibitors For Individual Pla(2) Enzymes Is Necessary In Order To Target Pla(2)-Specific Signaling Pathways,But It Is Challenging Due To The Observed Promiscuity Of Known Pla(2) Inhibitors. In The Current Work,We Present The Development And Application Of A Variety Of Synthetic Routes To Produce Pentafluoro,Tetrafluoro,And Trifluoro Derivatives Of Activated Carbonyl Groups In Order To Screen For Selective Inhibitors And Characterize The Chemical Properties That Can Lead To Selective Inhibition. Our Results Demonstrate That The Pentafluoroethyl Ketone Functionality Favors Selective Inhibition Of The Gvia Ipla(2),A Very Important Enzyme For Which Specific,Potent,Reversible Inhibitors Are Needed. We Find That 1,1,1,2,2-Pentafluoro-7-Phenyl-Heptan-3-One (Fkgk11) Is A Selective Inhibitor Of Gvia Ipla(2) (X-1(50) = 0.0073). Furthermore,We Conclude That The Introduction Of An Additional Fluorine Atom At The Alpha' Position Of A Trifluoromethyl Ketone Constitutes An Important Strategy For The Development Of New Potent Gvia Ipla(2) Inhibitors. DOI:10.1021/jm800649Q
专利号:US-6603070-B2 优先权日:2000-07-21 标题 :Convergent synthesis of multiporphyrin light-harvesting rods 发明人:LINDSEY JONATHAN S; LOEWE ROBERT S 权利人:UNIV NORTH CAROLINA STATE 摘要:The present invention provides a convergent method for the synthesis of light harvesting rods. The rods are oligomers of the formula A 1 (A b+1 ) b , wherein b is at least 1, A 1 through A b+1 are covalently coupled rod segments, and each rod segment A 1 through A 1+b comprises a compound of the formula X 1 (X m+1 ) m wherein m is at least 1 and X 1 through X m+1 are covalently coupled porphyrinic macrocycles. Light harvesting arrays and solar cells containing such light harvesting rods are also described, along with intermediates useful in such methods and rods produced by such methods.
专利号:US-4582903-A 优先权日:1984-08-17 标 题 :Synthesis of unsaturated hydantoins with an inexpensive catalyst 发明人:MIRVISS STANLEY B 权利人:STAUFFER CHEMICAL CO 摘要:Alkylidene or arylidene substituted hydantoins are produced by condensation of an aromatic or aliphatic aldehyde with hydantoin in the presence of at least one basic salt of an inorganic acid. The desired products are obtained in high yields.
专利号:US-5012000-A 优先权日:1989-10-30 标 题 :Total synthesis of chiral 2-amino-1,3-diols 发明人:ILLIG CARL R; WEIS ALEXANDER L 权利人:EASTMAN KODAK CO 摘要:A method for the preparation of chiral 2-amino-1,3-diols is disclosed. The method involves four steps including performance of an aldol condensation with a chiral oxazolidinone on an aldehyde, treating the aldol condensation product with an alkali metal azide, treating the product with a borohydride reagent and reducing the azide to an amine.
专利号:US-10808128-B2 优先权日:2018-06-11 标题 :Compounds as fluorescent probes, synthesis and applications thereof 发明人:GULYANI AKASH; RAJA SUFI OASIM; SIVARAMAN GANDHI 权利人:INST FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE INSTEM 摘要:The present disclosure relates to chemical dyes useful for staining and imaging of cells. In particular, the disclosure relates to compound of Formula I, method of preparation thereof, and it's use as a fluorescent probe for staining and/or imaging mitochondria in cells, tissues or animals, resulting in a range of applications including, but not limiting, to sensing local ordering or viscosity of mitochondria, tracking mitochondrial mobility, comparing & evaluating mitochondrial function, local ordering, microviscosity and dynamics. Said dyes have additional advantages including, but not limiting, to low toxicity, longer shelf-life, generate little or no reactive species upon long term light irradiation and do not perturb the functionality of the mitochondria in cells compared to prior art dyes.
专利号:US-2003111108-A1 优先权日:2000-07-21 标题:Convergent synthesis of multiporphyrin light-harvesting rods
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
参考文献:10.1007/s13369-026-11072-w 摘要:Tertyshnaya Y, Zhdanova K, Siracusa V, Bragina N. Physicochemical Properties of Metalloporphyrin–Polylactide Supramolecular System. Arab J Sci Eng. 2026 Jan 29;(). doi: 10.1007/s13369-026-11072-w.