CAS: 5619-09-0; Methyl 2-Amino-3-(1H-Indol-3-yl)Propanoate Hydrochloride

该化合物是基本氨基酸性试金酸酯的衍生物,改制为甲基酯盐盐,该化合物由于与免费试金酸盐相比溶性增强和活性增强,通常用于合成和制药研究;酯化和盐酸化盐的形成提高了其稳定性和处理特性,使之适合有机化学和药用化学应用中的受控反应;其性能(D,L-形态)允许立体化学研究的多功能性;该产品在需要精确结构修改的情况下,在开发生物活性和小型分子药物方面特别有用.

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CAS号7524-52-9 L-色氨酸甲酯盐酸盐 | CAS号14907-27-8 D-色氨酸甲酯盐酸盐 | CAS号19779-75-0 D,L-Tryptophan ... | CAS号81677-50-1 methyl 1-phenyl...

合成工艺路线路线简述

    📜Dl-色氨酸置于氯化亚砜体系中,用 甲醇 作为反应溶剂,化学反应生成 Dl-色氨酸甲酯盐酸盐
    参考文献:Process For Preparing Optically Active Tryptophans
    标题:Process For Preparing Optically Active Tryptophans
    摘要:介绍了一种dl-色氨酸的生化光学分辨方法,其中dl-色氨酸酰胺与能够产生酰胺酶的微生物的培养产物或其处理产物相互作用.在混合的dl-色氨酸酰胺中,L-色氨酸酰胺被不对称水解,形成光学活性的l-色氨酸,收率高,几乎所有的d-色氨酸酰胺都没有被水解.在分离l-色氨酸后,剩下的d-色氨酸酰胺很容易被水解,形成光学活性的d-色氨酸,收率高.

    海关参考信息

    专利信息


    专利号:US-2023220381-A1
    优先权日:2020-06-30
    标 题 :Dna-encoded functionalized aptamers
    发明人:SLEIMAN HANADI; LACROIX DE VIMEUR DE ROCHAME DONATIEN PHILIPPE MARIE; MCKEAGUE MAUREEN; HIRKA SERHII; SALIBA DANIEL; ANDERSON SHAUN IAN
    权利人:THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV
    摘要:It is provided the synthesis of an aptamer-like encoded oligomer (ALEnOmer), method of producing same and method of preparing a library of ALEnOmes. More particularly, the method of preparing ALEnOmer comprises coupling at least one phosphoramidite monomer with an orthogonal protecting group, and the ALEnOmer produces comprises a DNA coding strand covalently attached to an oligomer through a branching unit, wherein the oligomer has a degree of polymerization at least 5 and is an aptamer.

    专利号:US-4267344-A
    优先权日:1972-09-22
    标 题:N-Substituted N-carboxyanhydrides of α-amino acids and their application in the preparation of peptides
    发明人:HALSTROM JOHN B; KOVACS KAROLY G
    权利人:PROTEINKEMISK INST TILKNYTTET
    摘要:N-Substituted N-carboxyanhydrides of α-amino acids, useful in peptide syntheses, and peptide synthesis process using such compounds, are disclosed. The N-substituent is penta(lower alkoxy)benzyl, or optionally substituted 9-xanthyl, 9-thioxanthyl or 9-selenoxanthyl.

    专利号:EP-4540239-A1
    优先权日:2022-08-31
    标题 :Chiral synthesis of nornicotine and nicotine

    专利号:CN-107417685-B
    优先权日:2017-08-18
    标 题:Non-corresponding selective synthesis of 1-aryl-1H-pyridine [3,4-b ] indole derivatives

    专利号:EP-4332098-A1
    优先权日:2022-08-31
    标题:Chiral synthesis of nornicotine and nicotine

    专利号:WO-2024047152-A1
    优先权日:2022-08-31
    标题 :Chiral synthesis of nornicotine and nicotine

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/s10971-025-06824-3
    摘要:He H, Peng H, Liu F, Zhu X, Qu C, Guo C, Wang J. Periodic mesoporous organosilica with Serine-Tryptophan dipeptide framework by encapsulating curcumin to enhance ultraviolet shielding. J Sol-Gel Sci Technol. 2025 Jun 11;115(2):471–86. doi: 10.1007/s10971-025-06824-3.
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