CAS: 5521-55-1; 5-Methylpyrazine-2-Carboxylic Acid

相似化合物

61892-95-3 50866-30-3 98006-91-8

上下游产品

2,5-dimethyl-pyrazine 2-Hydroxymethyl-5-methylpyrazine 2-Acetoxymethyl-5-methylpyrazine 2-(chloromethyl)-5-methylpyrazine hydr°Chloride 2-Methylpyrazine methylammonium carbonate 5‐methylpyrazine-2-carboxamide 5-Methyl-pyrazine-2-carboxylic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester

2-氯甲基-5-甲基吡嗪置于sodium Hydroxide,Potassium Permanganate体系中,用 乙醇 作为反应溶剂,化学反应 0.67H,反应生成 5-甲基吡嗪-2-羧酸
参考文献:Iovel,I.; Goldberg,Yu.; Shymanska,M.,Organic Preparations And Procedures International,1991,Vol. 23,# 2,P. 188-190
标题:Iovel,I.; Goldberg,Yu.; Shymanska,M.,Organic Preparations And Procedures International,1991,Vol. 23,# 2,P. 188-190

专利信息

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-11542283-B2
优先权日:2018-05-28
标题 :Synthesis of peptide borate ester compound and use thereof
发明人：QIN YANRU
权利人:JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO LTD
摘要:Provided are a peptide borate ester compound or a pharmaceutically acceptable salt thereof, a preparation method therefor, and pharmaceutical use thereof. The peptide borate ester compound or pharmaceutically acceptable salt thereof has a structure as shown in Formula (I), and is useful in the preparation of proteasome inhibitors to treat solid tumors and hematoma.

专利号:US-5091066-A
优先权日:1987-11-19
标 题 :Electrochemical synthesis of 2-methyl-5-pyrazinoic acid
发明人：FOA MARCO; FORLINI FABRIZIO; GATTI NORBERTO; BORSOTTI GIAMPIERO
权利人:MINI RICERCA SCIENT TECNOLOG
摘要:There is disclosed a process for the preparation of 2-methyl-5-pyrazinoic acid consisting of electrochemically oxidizing a compound having formula: ##STR1## wherein X is --OH, Cl, Br, --O--CO--R, --O--SO 2 --R, in which R is a C 1 -C 5 alkyl radical, optionally substituted with F or Cl, or it is a C 6 -C 12 aryl radical, in an aqueous alkaline medium, at a temperature ranging from 20° C. to 90° C., using anodes coated with nickel oxide-hydroxide.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries