CAS: 5382-18-3; 4-Chloropiperidine

该化合物是一种杂交有机化合物,其特点是六人环,内含5个碳原子和1个氮原子,氯替代物位于管状环的第四位置,其分子分子式为C5H10ClN,其分子量为C5H10ClN,其分子量为C5H10ClN,其分子量为反映其成分.该化合物一般是一种无色至黄色的黄色液体,有独特的类似地雷的味道. 4-氯氟化烃在水和有机溶剂中溶解,可适用于各种有机合成和药物的应用.它经常被用作其他化学化合物合成的中间体,包括农用化学和药物.氯的出现会影响其再活动性和生物活动,使其成为医药化学的一个主题.与许多含氮化合物一样,它可能具有基本特性,允许它参与各种化学反应,包括核糖替代.在处理这一化合物时应采取安全防范措施,因为如果吸入或吸入,可能会对健康造成危害.

英文名称4-Chloropiperidine
中文名称4-氯哌啶
IUPAC名称4-chloropiperidine
其它别名Piperidine, 4-Chloro-; Gbpbxbuhzsokth-Uhfffaoysa-N; 4-Chloropiperidine; 4-Chloro-Piperidine
CAS编号5382-18-3
MFCD编号:MFCD09997828
EINECS号:611-055-0
分子式:C5H10ClN
分子量:119.6
产品CID: 1520902
产品分类有机原料→分子砌块→脂肪杂环类化合物→哌啶类化合物

相似结构搜索
产品信息参考;;;
InChIKey: GBPBXBUHZSOKTH-UHFFFAOYSA-N
InChI=1S/C5H10ClN/c6-5-1-3-7-4-2-5/h5,7H,1-4H2…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

相似化合物

5382-19-4 154874-94-9 67848-71-9

MSDS等安全信息

GHS象形图
GHS符号GHS02 & GHS05;
注释: Flame & Corrosion
危险类别易燃液体类别3
皮肤腐蚀类别1B
严重眼损伤类别1
警示词Danger(危险)
危险描述H226 |易燃液体和蒸气.
H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
防范说明P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501
危险等级8,3
UN编号2920.0
包装等级Ⅱ
安全声明S24/25

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

1-甲基-4-氯哌啶 4-Chloro-1-Methylpiperidine 5570-77-4

合成工艺路线路线简述

合成目标产物 4-Chloropiperidine 主要起始原料 4-Chloro-N-Methylpiperidine
(文献来源)合成步骤主要原料 4-Chloro-N-Methylpiperidine

4-Chloropiperidine Hydrobromide 以四氢呋喃,乙腈作为反应溶剂,化学反应 26.0H,反应生成 4-氯哌啶
参考文献:Synthesis Of 1-Tert-Butyl-4-Chloropiperidine: Generation Of An N-Tert-Butyl Group By The Reaction Of A Dimethyliminium Salt With Methylmagnesium Chloride
标题:Synthesis Of 1-Tert-Butyl-4-Chloropiperidine: Generation Of An N-Tert-Butyl Group By The Reaction Of A Dimethyliminium Salt With Methylmagnesium Chloride
摘要:Two Efficient Routes To 1-Tert-Butyl-4-Chloropiperidine Are Described. In The First Route,The Key Thionyl Chloride Mediated Chlorination Reaction Features The Use Of Tetrabutylammonium Chloride As An Additive That Effectively Suppresses The Formation Of An Elimination-Derived Side Product. In The Second Route,A Novel Alternative Synthesis Of 1-Tert-Butyl-4-Chloropiperidine Was Developed In Which The Tertiary Butyl Group On The Nitrogen Is Efficiently Generated Through The Addition Of Methylmagnesium Chloride To A Dimeth-Yliminium Salt In 71% Overall Yield.
DOI:10.1021/jo048047G

海关参考信息

2903110000-一氯甲烷及氯乙烷
2921199090-其他无环单胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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优先权日:2012-07-03
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专利号:US-9856241-B2
优先权日:2013-07-03
标题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

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优先权日:1995-05-05
标题 :Compounds, methods of their synthesis, pharmaceutical composition