CAS: 4810-41-7; N,N-Dimethylpyridine-3-Sulfonamide

相似化合物

4810-41-7 852388-77-3 4847-34-1

上下游产品

Pyridine-3-sulfonyl chloride N,N-Dimethyltrimethylsilylamine

📜吡啶-3-磺酰氯,N,N-二甲基三甲基硅胺 以 乙腈 作为反应溶剂,化学反应 1.0H,以99%的收率获得产物n,N-二甲基砒啶-3-磺酰胺
参考文献:Preparation Of Sulfonamides From N-Silylamines
标题:Preparation Of Sulfonamides From N-Silylamines
摘要:Sulfonamides Have Been Prepared In High Yields By The Reactions Of N-Silylamines With Sulfonyl Chlorides And Fluorides. In A Competition Experiment,The Sulfonyl Chlorides Were Found To Be Far More Reactive Than Sulfonyl Fluorides. The Chemistry May Be Used To Prepare Aliphatic,Aromatic,Tertiary,Secondary,And Primary Sulfonamides. It May Also Be Done In The Absence Of Solvent And The Byproduct Trimethylsilyl Chloride Recovered In Good Yield. Primary Sulfonamides Were Synthesized From The Sulfonyl Chloride With Aminotriphenyl Silane (Ph3Sinh2),A Conversion Demonstrated With The Synthesis Of The Carbonic Anhydrase Inhibitor,Acetazolamide. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2013.08.034

专利信息

专利号:WO-2023191400-A1
优先权日:2022-04-01
标题:Ethyl piperidine triazolo triazine derivatives, synthesis method therefor, and pharmaceutical composition containing same for prevention or treatment of cancer
发明人：JI SEUNGHEE; BYUN JOONSEOK; KIM JIWON; KIM DOYOUNG; KIM SEOHYUN; LEE JONGHYUN; JUNG SEUNGHEE; CHOI JONGRYOUL; KO DONG-HYUN; KIM DONGKYU; SON SEO HYUN; KANG JI YOON; JANG HYU JEONG; AHN SANG YEOP; KIM JI YONG; LEE SEO JIN
权利人:HK INNO N CORP; FUTURE MEDICINE CO LTD
摘要:The present invention relates to an ethyl piperidine triazolo triazine derivative, a synthesis method therefor, and a pharmaceutical composition including same for the prevention or treatment of cancer. Acting as an antagonist on an adenosine A2A receptor (A2AR), the derivative can exhibit efficacy for the prevention or treatment of various A2AR-related diseases, specifically, various cancers. When used in combination therapy with an immune checkpoint inhibitor, the derivative is expected to exhibit a remarkable synergistic effect in terms of anticancer activity.