CAS: 4691-65-0; Sodium ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-Hydroxy-9H-Purin-9-yl)Tetrahydrofuran-2-yl)Methyl Phosphate

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专利信息

专利号:US-2022089775-A1
优先权日:2019-05-31
标题:Multiply auxotrophic cell line for the production of recombinant proteins and methods thereof
发明人：CHASIN LAWRENCE; ZHANG QINGHAO; DU ZHIMEI
权利人:UNIV COLUMBIA; MERCK SHARP & DOHME
摘要:The present invention provides, inter alia, a multiply auxotrophic cell line that is deficient in genes encoding enzymes that catalyze steps in the de novo synthesis of the pyrimidine and purine pathways, such as, e.g., uridine monophosphate synthetase (UMPS) and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), respectively, for the production of recombinant proteins such as recombinant monoclonal and bispecific antibodies. Methods for preparing the multiply auxotrophic, in particular the doubly auxotrophic and octa-auxotrophic cell lines disclosed herein, methods for selecting a cell expressing a protein of interest, methods for producing a protein of interest, methods for optimizing the activity of a protein of interest, and kits for selecting a cell expressing a protein of interest, are also provided. In addition, recombinant proteins such as antibodies, including monoclonal and bispecific antibodies, made by the methods of the present disclosure are also provided.

专利号:US-3651097-A
优先权日:1968-03-18
标题:Synthesis of 2-methyl and 2-ethyl-3-hydroxy - 4 5 --dihydrofuran-4-one from monosaccharide 5-esters
发明人：OUWELAND GODEFRIDUS ANTONIUS M; PEER HENDRICUS GERARDUS
权利人:LEVER BROTHERS LTD
摘要:CERTAIN 2-ALKYL-3-HYDROXY-4,5-DIHYDROFURAN-4-ONES USEFUL AS FLAVOURING AGENTS, PARTICULARLY IN MEATY FLAVOURS CAN BE PREPARED FROM MONOSACCHARIDE 5-ESTERS. THE PHOSPHATE ESTERS ARE PARTICULARLY USEFUL AS STARTING MATERIALS. THE MONOSACCHARIDE 5-ESTERS ARE REACTED WITH NUCLEOPHILLIC AGENTS, SUCH AS DIETHYLAMINE, IN AN AQUEOUS MEDIUM AT A CAREFULLY CONTROLLED PH BETWEEN 2 AND 8 PREFERABLY IN THE PRESENCE OF A BUFFER SYSTEM.

专利号:US-2025109161-A1
优先权日:2021-11-30
标 题 :Heme, compositions and method of synthesis thereof
发明人：LEONG TAI WEI DAVID; ANG WEE HAN; LEONG LAI PENG; THAM JING RUI
权利人:NAT UNIV SINGAPORE
摘要:The present disclosure concerns heme and methods of synthesis thereof. The present disclosure also concerns to compositions and products thereof. The heme composition comprises heme at about 0.05% w/w to about 1% w/w relative to the heme composition and an antioxidant at about 0.25% w/w to about 5% w/w relative to the heme composition, wherein the heme is derived from protoporphyrin IX extracted from a plant, algal, bacterial and/or animal source.

专利号:US-12410437-B2
优先权日:2016-07-12
标 题:Incorporation of internal polya-encoded poly-lysine sequence tags and their variations for the tunable control of protein synthesis in bacterial and eukaryotic cells
发明人：DJURANOVIC SERGEJ; GREEN RACHEL
权利人:WASHINGTON UNIVERSITY ST LOUIS; UNIV JOHNS HOPKINS
摘要:The present disclosure relates to modulation of protein expression.

专利号:US-2024016143-A1
优先权日:2020-10-29
标题:Open cell hydrogel networks and methods for making and using the same
发明人：NIEDERHAUSER WILLIAM R; SAWYER CHARLES; SAWYER WALLACE G; SAWYER WILLIAM W
权利人:UNIV FLORIDA
摘要:In one aspect, the disclosure relates to open cell hydrogel networks, methods of making the same and baits formed from the same, methods of loading the same with attractant molecules and compositions, and methods of catching fish and/or other aquatic organisms using the same. The open cell hydrogel networks disclosed herein can be configured to have different properties based on the specific polymers used for synthesis as well as any initiators, catalysts, and/or crosslinkers, thus allowing the fabrication of suitable baits for a variety of target species. In some aspects, the open cell hydrogel networks can be used as a filter or drug delivery device.

专利号:US-11603533-B2
优先权日:2016-07-12
标题 :Incorporation of internal polya-encoded poly-lysine sequence tags and their variations for the tunable control of protein synthesis in bacterial and eukaryotic cells