CAS: 446-33-3; 5-Fluoro-2-Nitrotoluene

上下游产品

CAS号352-70-5 3-氟甲苯 | CAS号446-35-5 2,4-二氟硝基苯 | CAS号591-09-3 nitro acetate | CAS号7697-37-2 硝酸 | CAS号111566-79-1 4-iodo-2-methyl... | CAS号102791-92-4 1-(3-Methyl-4-n... | CAS号581-00-0 2-甲基-4-(4-吗啉)苯胺 | CAS号320-98-9 2-硝基-5-氟苯甲酸 | CAS号5367-32-8 3-甲基-4-硝基苯甲醚 | CAS号367-29-3 5-氟-2-甲基苯胺 | CAS号395-81-3 5-氟-2-硝基苯甲醛 | CAS号446-08-2 2-氨基-5-氟苯甲酸 | CAS号399-52-0 5-氟吲哚 | CAS号452-71-1 4-氟-2-甲基苯胺

2,4-二氟硝基苯置于magnesium Chloride体系中,用 N,N-二甲基乙酰胺,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 26.0H,反应生成 5-氟-2-硝基甲苯
参考文献:Bis(Dealkoxycarbonylation) Of Nitroarylmalonates: A Facile Entry To Alkylated Nitroaromatics
标题:Bis(Dealkoxycarbonylation) Of Nitroarylmalonates: A Facile Entry To Alkylated Nitroaromatics
摘要:详细介绍了一种通过双脱羧反应从取代硝基芳基丙二酸酯制备烷基化硝基芳烃的简便方法.
DOI:10.1055/s-2000-8209

专利信息

专利号:US-7125906-B2
优先权日:2002-04-03
标题 :Indole derivatives having anti-angiogenetic activity
发明人：ARNOULD JEAN-CLAUDE
权利人:ASTRAZENECA AB
摘要:The invention relates to the use of a compound of Formula (I), for the manufacture of a medicament to inhibit and/or reverse and/or alleviate symptoms of angiogenesis and/or any disease state associated with angiogenesis: n nwherein: X, p, q, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the description. The invention also related to use of compounds of Formula (I) as medicaments and also to novel compounds of Formula (I). The invention further provides pharmaceutical compositions of compounds of Formula (I) and processes for the synthesis of compounds of Formula (I).

专利号:WO-2012014109-A1
优先权日:2010-07-30
标题:Heterocyclic sulfonamides as inhibitors of transfer rna synthetase for use as antibacterial agents
发明人：DAS BISWAJIT; UPADHYAY DILIP J; PURNAPATRE KEDAR; GHOSH SOMA; KATOCH RITA
权利人:RANBAXY LAB LTD; DAS BISWAJIT; UPADHYAY DILIP J; PURNAPATRE KEDAR; GHOSH SOMA; KATOCH RITA
摘要:The present invention provides aromatic sulphonamides as tRNA synthetase inhibitors and process for their synthesis, pharmaceutical composition and method for treatment. Compounds disclosed can be used as antibacterial agents for the treatment or prevention of conditions caused by or contributed by aerobic and anaerobic Gram-positive pathogens, more particularly against bacterium, for example Staphylococcus, Enterococci and Streptococci . Compounds disclosed are used in particular for the treatment of skin and soft tissue infection, Formula (I).

专利号:US-12084422-B2
优先权日:2018-07-09
标 题 :Phenyl-n-quinoline derivatives for treating a RNA virus infection
发明人：SCHERRER DIDIER; TAZI JAMAL; MAHUTEAU-BETZER FLORENCE; NAJMAN ROMAIN; SANTO JULIEN; APOLIT CÉCILE
权利人:ABIVAX; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; INST CURIE
摘要:A compound of formula (I) or any of its pharmaceutically acceptable salt for use in the treatment and/or prevention of a RNA virus infection, and a RNA virus infection from group IV or V of the Baltimore classificationwherein R3 represents a chlorine atom or a hydrogen atom, R represents a (C1-C4)alkyl group, a (C3-C6)cycloalkyl group, a halogen atom, a (C1-C5)alkoxy group, a —SO2—NRaRb group, a —SO3H group, a —OH group, a —O—SO2—ORc group or a —O—P(â•?O)—(ORc)(ORd) group, R1 represents (i) a CF3 group, (ii) a (C1-C10)alkyl group, (iii) a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group or (iv) a phenyl group or a naphthyl group, and R2 represents a hydrogen atom, a (C1-C10)alkyl group, a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group and further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.

专利号:US-8163932-B2
优先权日:1998-03-31
标 题 :Substituted indolealkanoic acids
发明人：JONES MICHAEL LEE; GUNN DAVID; JONES JOHN HOWARD; VAN ZANDT MICHAEL C
权利人:JONES MICHAEL LEE; GUNN DAVID; JONES JOHN HOWARD; VAN ZANDT MICHAEL C; ALINEA PHARMACEUTICALS INC
摘要:Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.