专利号:US-2025049791-A1 优先权日:2023-08-03 标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof 发明人:SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO 权利人:UNIV NORTHWESTERN 摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.
专利号:US-4386953-A 优先权日:1980-10-02 标 题:Herbicidally active substituted 6-halogeno-tert.-butyl-1,2,4-triazin-5-ones 发明人:KRANZ ECKART; FINDEISEN KURT; SCHMIDT ROBERT; EUE LUDWIG 权利人:BAYER AG 摘要:A substituted 6-halogeno-tert.-butyl-1,2,4-triazin-5-one of the formula in which R1 is an amino or methyl group, R2 is an alkylmercapto, alkylamino or dialkylamino group, X is a halogen atom, and Y and Z each independently is a hydrogen or halogen atom, which possesses selective herbicidal activity. A synthesis involving the novel intermediates in which X, Y and Z have the above-mentioned meaning and Q is CN, CONH2 or COOH, is also shown.
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