CAS: 38899-05-7; Sodium ((2R,3R,4S,5R)-3,4,5,6-Tetrahydroxy-1-Oxohexan-2-yl)Sulfamate

Alkaline Earth Salt Of/The/ Methylsulfuric Acid 在 甲醇,Sodium Methylate体系中,获得 D-Glucosamine 2-Sulfate Sodium Salt
参考文献:Derivatives Of D-Glucose Containing The Sulfoamino Group1
标题:Derivatives Of D-Glucose Containing The Sulfoamino Group1
摘要:
Doi:10.1021/Ja01575A058

专利信息

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

专利号:US-12054508-B1
优先权日:2019-04-16
标 题 :Compositions and methods for sulfation of carbohydrates and peptides via electron-deficient aryl sulfate diesters
发明人：NIU JIA; LIU CHAO; YANG CANGJIE
权利人:THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a facile strategy to introduce electron-deficient aryl sulfate diesters to silylated hydroxyl groups of carbohydrates and amino acids, among other substrates, wherein selective hydrolysis and the removal of an electron-deficient aromatic group allows for the efficient generation of sulfated carbohydrates, peptides, and other compounds. The incorporation of electron-deficient aryl sulfate diesters in the early stage of the synthesis of glycans, peptides, and the like, disclosed herein avoids time-consuming protecting group manipulations, simplifies the purification of sulfated products, and improves the overall yield and efficiency. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-2022251128-A1
优先权日:2019-05-17
标 题:Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphodiester linkages
发明人：MCPHERSON ANDREW K; RODRIGUEZ ANDREW A; CAPALDI DANIEL C
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods for synthesizing oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage. In certain embodiments, the present disclosure provides oxidation reagents that produce low amounts of unwanted phosphate diester impurities in oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage.

专利号:US-8771995-B2
优先权日:2005-05-12
标 题 :Enzymatic synthesis of sulfated polysaccharides
发明人：LIU JIAN; LINHARDT ROBERT J; AVCI FIKRI Y; MUNOZ AVA M; CHEN JINGHUA
权利人:LIU JIAN; LINHARDT ROBERT J; AVCI FIKRI Y; MUNOZ AVA M; CHEN JINGHUA; UNIV NORTH CAROLINA; RENSSELAER POLYTECH INST
摘要:Heparin is synthesized from a polysaccharide comprised of a 1-4 glycosidically linked alternating polymer of uronic acid and glucosamine residues, wherein the uronic acid is selected from iduronic and glucuronic acid, wherein the glucosamine is partially N-sulfated; by a series of selective reactions catalyzed by recombinant enzymes.

专利号:WO-2024105271-A1
优先权日:2022-11-17
标 题:Preparation of medium molecular weight heparin
发明人：Bhogal Pervinder; BRACKETT JOHN; RUSHTON GRAHAM
权利人:GLYCOS BIOMEDICAL LTD
摘要:The present invention provides the synthesis of medium molecular weight heparins.