CAS: 363-52-0; 3-Fluorocatechol

上下游产品

CAS号86944-77-6 (1R,2R)-3-fluor... | CAS号28177-50-6 2-氟-6-碘苯酚 | CAS号699-92-3 2-羟基-3-氟苯乙酮 | CAS号462-06-6 氟苯 | CAS号1446354-13-7 6-fluoro-3,4-di... | CAS号394-50-3 3-氟水杨醛 | CAS号367-12-4 2-氟苯酚 | CAS号73943-41-6 2-氟-6-甲氧基苯酚 | CAS号456-49-5 间氟苯甲醚 | CAS号29650-44-0 (2-fluorophenyl... | CAS号394-64-9 1-氟-2,3-二甲氧基苯 | CAS号226555-35-7 1,2-二乙氧基-3-氟苯 | CAS号365458-32-8 2-(2,4-difluoro... | CAS号943126-88-3 4-fluoro-2,3-di... | CAS号943830-74-8 1,2-亚甲基二氧基-3-氟苯

📜氟苯置于palladium On Activated Charcoal 氧气体系中,用 甲醇 用作溶剂,30.0 °C,101.33 Kpa 条件下,反应 72.0H,反应生成3-氟邻苯二酚
参考文献:酶法和化学酶法合成3-取代邻苯二酚的比较研究
标题:酶法和化学酶法合成3-取代邻苯二酚的比较研究
摘要:使用异种催化剂(pd / C)和萘类顺式二醇脱氢酶均可将一系列的顺式-二氢二醇代谢物从细菌双加氧酶催化的恶臭假单胞菌uv4氧化为单取代苯底物得到存在于所述重组菌株的全细胞大肠杆菌dh5α(puc129:Nar乙).已经对这两种途径对3-取代的邻苯二酚的优点进行了比较研究,发现这两种方法是互补的.已经发现使用氘标记的甲苯顺式-二氢二醇在酶促和化学酶促条件下邻苯二酚形成的机理相似,包括c-1处羟基的区域选择性氧化.已经实现了将生物催化步骤(双加氧酶催化的顺式-二羟基化)与化学催化步骤(pd / C催化的脱氢)组合成一锅法从母体取代的苯底物中生成邻苯二酚的潜力.
Doi:10.1002/adsc.200600437

专利信息

专利号:US-10597340-B2
优先权日:2013-05-10
标 题:Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination
发明人：SADEGHI SAMAN; HE QINGGANG; LEBEDEV ARTEM
权利人:UNIV CALIFORNIA
摘要:Provided herein are methods and compositions for the electrochemical selective radiofluorination of aromatic molecules. The resulting fluorine-18 labeled compounds are ideal radionuclides for use in Positron Emission Tomography (PET); they are also difficult to radiolabel efficiently and with high specific activity using existing approaches. For example, radiopharmaceuticals such as [F18]L-DOPA, which is indispensable in PET brain disease imaging, may be made electrochemically with high radiochemical yield and high specific activity using 18F-. The invention process described herein opens new possibilities and provides wider access to PET tracers such as 18F-L-Dopa, since 18F- is much more widely available than the 18F 2 , currently used for synthesis of electron rich substrates.

专利号:US-2011104055-A1
优先权日:2002-05-31
标题:Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
发明人：SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
摘要:Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.

专利号:US-5047592-A
优先权日:1989-08-21
标题 :Selective hydrogenolysis process
发明人：CARPENTER JOEL F
权利人:ETHYL CORP
摘要:A relatively simple, economical process for the synthesis of epinine and related compounds is described. The process involves subjecting adrenalone, epinephrine or their respective congeners to selective hydrogenolysis using hydrogen and a metal hydrogenolysis catalyst such as palladium, platinum, rhodium or nickel. Preferably the reaction is conducted in a non-oxidizing acidic liquid reaction medium, such as in aqueous hydrochloric acid.

专利号:US-2016137567-A1
优先权日:2013-05-10
标题 :Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination

专利号:RU-2114852-C1
优先权日:1991-12-12
标题 :Cephem syn-isomer derivatives, method of their synthesis and pharmaceutical composition based on thereof