CAS: 351-54-2; 3-Fluoro-4-Methoxybenzaldehyde

该化合物是一种含分子式C8H7FO2的氟芳代正丁,该化合物的特征是:准体位的甲氧基组和相对于甲醛功能的元位的氟原子,这加强了其在有机合成中的回活动性和选择性.其电子脱钩和捐赠替代成分使它成为药物,农用化学品和精美化学的多用途中间体.氟原子改善了代谢稳定性和生物活性分子的结合性,而甲氧基组则有助于溶性和进一步的功能化.这一化合物在交叉反应,核分裂性代用品以及作为异环合成的前体方面特别宝贵.高纯度等级确保了研究和工业应用的一致性.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号321-28-8 2-氟苯甲醚 | CAS号1191-17-9 1,1-dichloro-2-... | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号3907-15-1 3-氟-4-甲氧基苯甲酰氯 | CAS号331-62-4 3-氟-4-甲氧基苯腈 | CAS号351-52-0 3-氟-4-甲氧基苄基氯 | CAS号100-97-0 乌洛托品 | CAS号399-55-3 2-氟-4-甲基苯甲醚 | CAS号331-61-3 3-氟-4-甲氧基苄基溴 | CAS号7647-01-0 盐酸 | CAS号404-90-0 3-氟-4-甲氧基苯乙腈 | CAS号350-29-8 3-氟-4-羟基苯甲酸 | CAS号403-20-3 3-氟-4-甲氧基苯甲酸 | CAS号83802-71-5 5-氟-2,3-二氢-6-甲氧... | CAS号96047-32-4 3-氟-4-甲氧基苯甲醇 | CAS号586-22-1 1-(3-氟-4-甲氧基苯基)丙-1-酮 | CAS号320-70-7 3-氟-4-甲氧基-5-硝基苯甲醛 | CAS号329-46-4 3-氨基-5-氟-4-甲氧基苯甲酸甲酯 | CAS号175968-61-3 4-(苄氧基)-3-氟苯甲醛 | CAS号192702-79-7 3-氟-4-甲基苯甲醇

合成工艺路线路线简述

    2-氟苯甲醚置于四氯化钛体系中,用 二氯甲烷 用作溶剂,化学反应生成3-氟-4-甲氧基苯甲醛
    参考文献:Method For Treating Patient Having Precancerous Lesions With A Combination Of Pyrimidopyrimidine Derivatives And Esters And Amides Of Substituted Indenyl Acetic Acides
    标题:Method For Treating Patient Having Precancerous Lesions With A Combination Of Pyrimidopyrimidine Derivatives And Esters And Amides Of Substituted Indenyl Acetic Acides
    摘要:取代基茚基乙酸和嘧啶并嘧啶衍生物的组合物在结肠息肉的治疗和抑制肿瘤细胞生长方面是有用的.

    海关参考信息

    专利信息


    专利号:US-5679864-A
    优先权日:1995-11-03
    标题:Process for the synthesis of curcumin-related compounds
    发明人:KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
    权利人:GENE PRINT INC
    摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

    专利号:US-5175302-A
    优先权日:1987-07-13
    标 题 :Nucleophilic fluoroalkylation of aldehydes
    发明人:STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

    专利号:US-4837327-A
    优先权日:1987-07-13
    标 题 :Process for nucleophilic fluoroalkylation of aldehydes
    发明人:STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

    专利号:US-4999429-A
    优先权日:1989-01-09
    标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
    发明人:STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

    专利号:WO-0053313-A2
    优先权日:1999-03-09
    标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

    专利号:WO-9811438-A1
    优先权日:1996-09-13
    标题 :Synthesis of quinazolinone libraries and derivatives thereof
    常州市三灵化工有限公司
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    合成参考文献


    摘要:OʼBrien, M.; Polyzos, A., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 244.
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    摘要:Amii, H., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
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