CAS: 3328-70-9; 4-Hydroxyisophthalaldehyde

上下游产品

CAS号100-97-0 乌洛托品 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号23731-06-8 5-(氯甲基)-2-羟基苯甲醛 | CAS号1761-62-2 5-碘水杨醛 | CAS号67-66-3 氯仿 | CAS号108-95-2 苯酚 | CAS号50-00-0 甲醛 | CAS号89-95-2 邻甲基苄醇 | CAS号636-46-4 4-羟基间苯二甲酸 | CAS号139-85-5 原儿茶醛; 原二茶醛; 茶酚甲... | CAS号2937-61-3 2-羟基-1,3,5-苯三甲醇 | CAS号74901-08-9 2-羟基-5-(羟基甲基)苯甲醛

📜2-羟基-5-氯甲基苯甲醛置于乌洛托品,溶剂黄146体系中,用 水 作为反应溶剂,化学反应 1.0H,以66 G的收率获得产物4-羟基间苯二甲醛
参考文献:作为新型黄嘌呤氧化酶抑制剂的2-(4-烷氧基-3-氰基)苯基-6-氧代-1,6-二氢嘧啶-5-羧酸衍生物的设计,合成和生物学评估.
标题:作为新型黄嘌呤氧化酶抑制剂的2-(4-烷氧基-3-氰基)苯基-6-氧代-1,6-二氢嘧啶-5-羧酸衍生物的设计,合成和生物学评估.
摘要:在我们以前的研究中,我们报道了一系列1-羟基-2-苯基-1H-咪唑-5-羧酸衍生物,它们具有出色的体外黄嘌呤氧化酶(xo)抑制能力.为了进一步研究这些化合物的结构-活性关系,将咪唑环转化为嘧啶环,以设计2-(4-烷氧基-3-氰基)苯基-6-氧代1,6-二氢嘧啶-5-羧酸(8A-8J),2-(4-烷氧基-3-氰基)苯基-4-甲基-6-氧代-1,6-二氢嘧啶-5-羧酸(9C,9E,9J,9L)和2-(4-烷氧基-3-氰基)苯基-6-亚氨基-1,6-二氢嘧啶-5-羧酸(10C,10E,10J,10L).这些化合物具有出色的体外xo抑制能力,Ic50值范围为0.0181μm至0.5677μm.具体而言,化合物10C和10E的ic50值分别为0.0240μm和0.0181μm,成为最有效的xo抑制剂,其效价与非布索坦相当.结构-活性关系分析表明,嘧啶环的4位甲基可能会破坏该效能,而当羰基变为亚氨基
DOI:10.1016/j.Ejmech.2019.07.061

专利信息

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:RU-2186055-C2
优先权日:1995-05-24
标 题 :Method of synthesis of derivatives 3-carboxy-4-hydroxybenzaldehyde, method of synthesis of 4-hydroxybenzaldehyde, methods of synthesis of vanillin and ethylvanillin

专利号:EP-0739349-B1
优先权日:1994-01-10
标题:Polymer-supported solution synthesis of oligosaccharides

专利号:EP-0739349-A1
优先权日:1994-01-10
标 题 :Polymer-supported solution synthesis of oligosaccharides

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.

专利号:CN-120004787-A
优先权日:2023-11-14
标题 :Design, synthesis and activity research of in-situ detection nitroreductase fluorescent probe