CAS: 21035-59-6; 2-[(Methylamino)Methyl]Pyridine

相似化合物

134807-28-6 6971-57-9 100868-72-2

上下游产品

CAS号1121-60-4 吡啶-2-甲醛 | CAS号6959-47-3 2-氯甲基吡啶盐酸盐 | CAS号74-89-5 氨基甲烷 | CAS号134807-29-7 2-[[N-(tert-but... | CAS号3731-51-9 2-(氨甲基)吡啶 | CAS号56625-03-7 N-(2-吡啶基甲基)甲酰胺 | CAS号74-88-4 碘甲烷 | CAS号134807-28-6 N-B°C-2-氨甲基吡啶 | CAS号6144-78-1 N-甲基吡啶甲酰胺 | CAS号43071-19-8 2-[(二甲氨基)甲基]吡啶 | CAS号27643-19-2 N-甲基-1-(哌啶-2-基)甲胺 | CAS号23950-04-1 邻尼古丁

吡啶-2-甲醛置于sodium Tetrahydroborate体系中,用 甲醇,苯 用作溶剂,化学反应 3.0H,反应生成2-[(甲氨基)甲基]吡啶
参考文献:具有桥头氮 52 的化合物--2-烷基全氢咪唑并[3,4-A]吡啶的核磁共振谱和立体化学
标题:具有桥头氮 52 的化合物--2-烷基全氢咪唑并[3,4-A]吡啶的核磁共振谱和立体化学
摘要:与全氢恶唑并[3,4-A]吡啶和全氢噻唑并[3,4-A]吡啶相反,它们在室温下在cdcl3溶液中采用平衡,其中含有约70%的与o-或s-平衡的互变构象异构体在顺式融合的构象异构体中,发现 2-烷基全氢咪唑并[3,4-A]吡啶采用含有>98% 的反式融合构象异构体的平衡.2-甲基全氢咪唑并[3,4-A]吡啶的NMR参数与1,2-二甲基全氢咪唑并[3,4-A]吡啶的两种异构体的NMR参数的比较表明前一种化合物在两种反式融合构象异构体之间达到平衡,大约 83% 的构象包含氮孤对电子的反式排列.这些观察结果是根据广义异头效应来解释的.
Doi:10.1002/mrc.1260250808

专利信息

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-6252082-B1
优先权日:1997-01-16
标 题 :Pyridone derivatives, their preparation and their use as synthesis intermediates
发明人：LASSALLE GILBERT; BELLEVERGUE PATRICE; BOURBIER JEAN-CLAUDE; GALTIER DANIEL; MARTIN VALERIE
权利人:SANOFI SYNTHELABO
摘要:The invention concerns compounds of formula (I)in which: R is -NO2 or -NHR3, R3 being hydrogen, -COR4 (R4 selected among (C1-C4) alkyl, aryl and aryl (C1-C4) alkyl, -COOR5 (R5 selected among (C1-C4) alkyl and aryl (C1-C4) alkyl), -CONHR6 or SO2R6 (R6 selected among (C1-C5) alkyl, aryl and aryl(C1-C4) alkyl), -SO2NR7R8 (R7 and R8 independently of each other represent hydrogen or (C1-C4) alkyl or form with the nitrogen atom a morpholine group), aryl (C1-C4) alkyl, R1 is a (C1-C4) alkyl group linear or branched, cyclo (C3-C8) alkyl, aryl optionally substituted, aryl (C1-C4) alkyl optionally substituted, heteroaryl, R2 is a hydrogen atom, a (C1-C4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a -CH2-, -SO2 or -NR1- group and Y is a hydrogen atom or (C1-C6) alkyl. The invention is applicable to synthesis intermediates.

专利号:US-2008194629-A1
优先权日:2005-05-03
标题 :3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors
发明人：BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
权利人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
摘要:The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-piperidine compound, and/or a method of treatment comprising administering a 3,5-piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

专利号:US-9770029-B2
优先权日:2008-07-09
标题:Pesticidal active mixtures comprising isoxazoline compounds I
发明人：KOERBER KARSTEN; KAISER FLORIAN; LANGEWALD JUERGEN
权利人:BASF SE
摘要:The present invention relates to pesticidal mixtures comprising as active compoundsn 1) at least one isoaxazoline compound I of the formula (I) nn n n n n n n n n n wherein R 1 , R 2 , R 3 , R 4 , R 5 and A are defined in the description; n and n 2) at least one active compound II selected from a group A comprising acteylcholine esterase inhibitors, GABA-gated chloride channel antagonists, sodium channel modulators, nicotinic acteylcholine receptor agonists/antagonists, chloride channel activators, juvenile hormone mimics, compounds affecting the oxidative phosphorylation, inhibitors of the chitin biosynthesis, moulting disruptors, inhibitors of the MET, voltage-dependent sodium channel blockers, inhibitors of the lipid synthesis and other compounds as defined in the description, in synergistically effective amounts. n n n The invention relates further to methods and use of these mixtures for combating insects, arachnids or nematodes in and on plants, and for protecting such plants being infested with pests, especially also for protecting plant propagation material as like seeds.

专利号:US-9701686-B2
优先权日:2009-12-04
标题:Tricyclopyrazole derivatives
发明人：DISINGRINI TERESA; MANTEGANI SERGIO; VARASI MARIO
权利人:NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.