CAS: 19764-32-0; (R)-2-Acetamido-3-(4-Hydroxyphenyl)Propanoic Acid

上下游产品

CAS号64896-33-9 2-乙酰基-3-(4-羟基苯基)-丙烯酸 | CAS号556-02-5 D-酪氨酸 | CAS号108-24-7 乙酸酐 | CAS号23525-90-8 l-N-acetyl tyro... | CAS号22862-76-6 茴香霉素

📜(Z)-α-Acetamido-P-Hydroxycinnamic Acid置于rhodium(I)-(S,S)-Skewphos Complexes 氢气体系中,用 四氢呋喃 用作溶剂,化学反应生成N-乙酰-D-酪氨酸
参考文献:Asymmetric Synthesis. Asymmetric Catalytic Hydrogenation Using Chiral Chelating Six-Membered Ring Diphosphines
标题:Asymmetric Synthesis. Asymmetric Catalytic Hydrogenation Using Chiral Chelating Six-Membered Ring Diphosphines
摘要:
Doi:10.1021/ja00399A023

专利信息

专利号:US-7282606-B2
优先权日:2005-07-13
标题:Process for preparation of tamsulosin and its aralkylamine derivatives
发明人：JIH RU HWU; TSAY SHWU CHEN; MAGENDRAN BALAACHARY; CHAKRABORTY SUBHASISH K; DAS ASISH R; SHEU KUEN WANG; SHU CHUN MEI; LU CHIN KUN; CHANG WEI MIN
权利人:TAIWAN BIOTECH CO LTD
摘要:The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(−)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. n n n n n n n n n n Tamsulosin hydrochloride (R 1 =Et, R 2 =Me, in its hydrochloride salt form) is an antagonist of α-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.

专利号:US-9783800-B2
优先权日:2014-02-03
标 题:Method for producing peptides having azole-derived skeleton
发明人：SUGA HIROAKI; GOTO YUKI; KATO YASUHARU
权利人:UNIV TOKYO
摘要:Object of the present invention is to develop an artificial synthesis system of various peptides having an azole derivative structure and develop a library of such peptides. The present invention provides a method of producing a peptide having, in the backbone thereof, an azole derivative structure comprising the step of: synthesizing a substrate peptide of an azoline structure introducing enzyme having, in the modified region thereof, at least any one of the following amino acids, n n[in any of the compounds,n X 1 represents a group selected from the group consisting of SH, OH, NH 2 , SR 1 , OR 1 , NHR 1 , and N 3 (R 1 represents a protecting group), X 2 represents an easily eliminable group; and X 3 represents hydrogen or a substituted or unsubstituted alkyl or aryl group having from 1 to 10 carbon atoms]; reacting the substrate peptide with an azoline structure introducing enzyme to obtain a peptide having an azoline derivative structure; and converting the azoline derivative structure of the resulting peptide into an azole derivative structure by inducing an HX 2 elimination reaction of X 2 group.