专利号:EP-0951464-B1 优先权日:1996-11-22 标题:N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 发明人:WU JING; THORSETT EUGENE D; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; JOHN VARGHESE; FANG LAWRENCE Y; AUDIA JAMES E 权利人:ELAN PHARM INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6333351-B1 优先权日:1996-11-22 标题:N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:WU JING; THORSETT EUGENE D; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; JOHN VARGHESE; FANG LAWRENCE Y; AUDIA JAMES E 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6767918-B2 优先权日:1996-11-22 标 题 :N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:WU JING; THORSETT EUGENE D; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; JOHN VARGHESE; FANG LAWRENCE Y; AUDIA JAMES E 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6486350-B1 优先权日:1998-09-30 标 题:Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide 发明人:AUDIA JAMES E; HYSLOP PAUL A; NISSEN JEFFREY S; THOMPSON RICHARD C; TUNG JAY S; TANNER LAURA I 权利人:ELAN PHARM INC; LILLY CO ELI 摘要:Disclosed are biological reagents which comprise compounds that inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of beta-amyloid peptide.
专利号:US-9917260-B2 优先权日:2013-08-23 标题 :Compounds with terminal heteroarylcyanovinylene groups and their use in organic solar cells 发明人:SUNDARRAJ SUDHAKAR; EICKHOFF CHRISTIAN; BAHULAYAN SHEEJA; SEND ROBERT; NISHIMAE YUICHI; REICHELT HELMUT; TANABE JUNICHI; ERK PETER 权利人:BASF SE 摘要:The present invention relates to a photoactive material comprising a donor substance and an acceptor substance, wherein the donor substance comprises or consists of one or more compounds of formula (I) described herein, or the acceptor substance comprises or consists of one or more compounds of formula (I) described herein, or the donor substance comprises or consists of a first compound of formula (I) described herein and the acceptor substance comprises a second compound of formula (I) described herein with the proviso that the first and second compound are not the same, as well as to an organic solar cell comprising said photoactive material. The present invention also relates to a photoelectric conversion device comprising or consisting of two or more organic solar cells comprising said photoactive material and to compounds of formula (I) as described herein for use as donor substance or as acceptor substance in a photoactive material, Further, the present invention relates to the use of a compound of formula (III) as described herein in the synthesis of a compound of formula (I)as described herein.
专利号:US-2003191119-A1 优先权日:1996-11-22 标 题 :N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
参考标题:Efficient Copper(I)-Catalyzed C-S Cross-Coupling Of Thiols With Aryl Halides In An Aqueous Two-Phase System 作者:Xin-Yan Zhang,Xiao-Yan Zhang,Sheng-Rong Guo |发布日期:2011.2.1 摘要:A Mild And Convenient C-S Bond Formation Reaction Catalyzed By Cui/l-Proline In An Aqueous Two-Phase System Was Achieved, Providing A Simple Method For The Synthesis Of Aryl Sulfides In Good Yields.
合成参考文献
摘要:Ronson, T. O.; Fairlamb, I. J. S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 187.