CAS: 1517-68-6; (S)-1-Phenylpropan-2-Ol

相似化合物

698-87-3 2114-33-2 5040-23-3

上下游产品

CAS号103-79-7 苯基丙酮 | CAS号4518-66-5 (1S,2S)-(-)-1-苯基环氧丙烷 | CAS号108-05-4 乙酸乙烯酯 | CAS号698-87-3 1-苯基-2-丙醇 | CAS号108-86-1 溴苯 | CAS号16088-62-3 S-环氧丙烷 | CAS号75-24-1 三甲基铝 | CAS号122-78-1 2-苯基乙醛 | CAS号61393-94-0 (R)-(2,3-epoxyp... | CAS号698-87-3 1-苯基-2-丙醇 | CAS号103-79-7 苯基丙酮 | CAS号2323-36-6 1-[4-[2-[(4-chl... | CAS号33817-09-3 脱氧麻黄碱 | CAS号1572-95-8 (R)-1-苯基-2-丙醇

📜苯基丙酮置于(S)-Selective Alcohol Dehydrogenase From Rhodococcus Ruber体系中,用 Aq. Phosphate Buffer,异丙醇,乙腈 用作溶剂,以99%的收率获得
参考文献:通过漆酶和酮还原酶或ω-转氨酶的顺序作用,将酮肟一锅转化为旋光性醇和胺
标题:通过漆酶和酮还原酶或ω-转氨酶的顺序作用,将酮肟一锅转化为旋光性醇和胺
摘要:通过将漆酶催化的脱肟与酮还原(酮还原酶,Kred)或生物胺化(ω-转氨酶,ω-Ta)相继偶联,开发了一种酶法一锅法,用于将前手性酮肟不对称转化为醇或胺.中等的.正确选择生物催化剂后,相应的产品的对映体过量非常好,醇的总转化率从83%到> 99%,胺的总转化率从70%到> 99%.同样,仅使用1%(w / W)的cremophor®(一种聚乙氧基化蓖麻油)作为助溶剂,可使手性醇级联反应中的浓度达到100 Mm.
Doi:10.1002/cctc.201801900

专利信息

专利号:US-7750135-B2
优先权日:2006-07-28
标题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols
发明人：ZEIKUS J GREGORY; ZIEGELMANN-FJELD KARLA I; VIEILLE CLAIRE
权利人:UNIV MICHIGAN STATE
摘要:The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.

专利号:US-2008220487-A1
优先权日:2006-07-28
标题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols

专利号:WO-2008013949-A2
优先权日:2006-07-28
标 题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols