专利号:US-12304912-B2 优先权日:2020-07-28 标 题 :Fused bicyclic RAF inhibitors and methods for use thereof 发明人:BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA 权利人:JAZZ PHARMACEUTICALS IRELAND LTD 摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.
专利号:EP-4188923-A1 优先权日:2020-07-28 标题 :Chiral synthesis of fused bicyclic raf inhibitors
专利号:WO-2022023450-A1 优先权日:2020-07-28 标题:Chiral synthesis of fused bicyclic raf inhibitors
专利号:CN-116348465-A 优先权日:2020-07-28 标 题:Chiral Synthesis of Fused Bicyclic RAF Inhibitors
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合成参考文献
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