CAS: 139122-19-3; 4-(2-Hydroxyethyl)Indolin-2-One

上下游产品

CAS号139122-17-1 4-[2-(苯甲酰氧基)乙基]... | CAS号22901-09-3 2-(2-溴乙基)苯甲醛 | CAS号120427-95-4 4-(2-溴乙基)-3-氯-1... | CAS号139122-18-2 4-[2-(苯甲酰基氧基)乙基... | CAS号493-05-0 异色满 | CAS号95033-78-6 1-羟基异苯并二氢吡喃 | CAS号120427-96-5 4-(2-溴乙基)氧化吲哚 | CAS号91374-21-9 罗匹尼罗 | CAS号139122-20-6 4-(2'-羟乙基)氧化吲哚对甲苯磺酸酯

4-(2'-溴乙基)-3-氯-1,3-二氯-2-吲哚酮置于palladium On Activated Charcoal 盐酸,Sodium Hypophosphite体系中,用 乙醇,水,乙酸乙酯 用作溶剂,化学反应 27.08H,反应生成1,3-二氢-4-(2-羟乙基)-2H-吲哚-2-酮
参考文献:罗匹尼罗的一些合成方法(sk&f 101468-A):一种有效的多巴胺受体激动剂
标题:罗匹尼罗的一些合成方法(sk&f 101468-A):一种有效的多巴胺受体激动剂
摘要:描述了三种新的制备罗匹尼罗的途径(sk&f 101468-A,1),每个途径都涉及从β-硝基苯乙烯制备3型3-氯代吲哚中间体这一关键步骤.还描述了作为酯的直接前体的磺酸酯17A-C相对于溴化物11的优越性.
Doi:10.1002/jhet.5570320334

专利信息

专利号:WO-0056709-A1
优先权日:1999-03-24
标 题:Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
权利人:SUGEN INC; TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6465507-B2
优先权日:2000-02-28
标题 :3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; MILLER TODD A; LI XIAOYUAN; ZHANG RUOFEI; CUI JINRONG; HUANG PING; WEI CHUNG CHUN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6689806-B1
优先权日:1999-03-24
标 题 :Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS JR G DAVIS; LI XIAOYUAN; LIANG CONGXIN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:WO-2005113561-A1
优先权日:2004-05-20
标 题:Cyclicsulfonate pyrrole indolinones as kinase inhibitors
发明人：TANG PENG CHO; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD
权利人:SUGEN INC; TANG PENG CHO; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD
摘要:The invention provides compounds of structure of formula (I), and methods of their synthesis and use. Preferred compounds are useful as therapeutic agents, particularly for protein kinase related disorders such as cancer.