CAS: 131707-24-9; Ethyl 6-Bromo-5-Hydroxy-1-Methyl-2-((Phenylthio)Methyl)-1H-Indole-3-Carboxylate

相似化合物

131707-24-9 141061-97-4 1704066-63-6

上下游产品

阿比朵尔 Arbidol 131707-25-0
5-乙酰氧基-6-溴-2-溴甲基-1-甲基吲哚-3-甲酸乙酯 1-Methyl-2-Bromomethyl-3-Ethoxycarbonyl-5-Acetoxy-6-Bromoindole 110543-98-1
美卡比酯 Mecarbinate 15574-49-9
5-乙酰氧基-1,2-二甲基吲哚-3-羧酸乙酯 Ethyl 5-Acetoxy-1,2-Dimethylindole-3-Carboxylate 40945-79-7
5-羟基-2-甲基吲哚-3-羧酸乙酯 Ethyl 5-Hydroxy-2-Methylindole-3-Carboxylate 7598-91-6
5-乙酰氧基-2-甲基吲哚-3-羧酸乙酯 Ethyl 5-Acetyloxy-2-Methyl-1H-Indole-3-Carboxylate 20862-91-3

4-硝基苯基乙酸酯置于indium(III) Bromide,溴,Copper Diacetate,Palladium Diacetate,铁粉,Potassium Carbonate,氯化铵,Sodium Hydroxide,过氧化苯甲酰体系中,用 甲醇,乙醇,二氯甲烷,氯仿,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 22.0H,反应生成6-溴-5-羟基-1-甲基-2-(苯基硫甲基)吲哚-3-甲酸乙酯
参考文献:一种盐酸阿比朵尔一水合物的制备方法
标题:一种盐酸阿比朵尔一水合物的制备方法
摘要:本发明公开了一种盐酸阿比朵尔的制备方法,本发明创新性的采用原料廉价易得的对硝基苯酚为原料,经乙酰化,硝基还原,吲哚环反应,甲基化反应,溴代,苯硫酚化和脱保护,Mannich反应,成盐得到盐酸阿比朵尔;整个合成过程反应条件温和,原料来源方便,产品性状好,收率高,副产物少,反应选择性和纯度高,对环境友好,生产成本低,适合工业化生产;避免了现有技术中的选择性差,副产物多,收率较低,避免了使用贵重的催化剂以及环境污染大的试剂的弊端.

专利信息

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-12098115-B2
优先权日:2016-09-15
标 题:Methods and compositions for terpenoid synthesis
发明人：GRENNING ALEXANDER JAMES
权利人:UNIV FLORIDA
摘要:In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:WO-2022170218-A1
优先权日:2021-02-05
标题:Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates
发明人：QIN TIAN; YANG YANGYANG; TSIEN JET
权利人:UNIV TEXAS
摘要:Disclosed herein are methods of synthesizing compounds of the formula (I) wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to install aryl bioisosteres.

专利号:WO-2024061972-A1
优先权日:2022-09-20
标 题:Methods and platform for chemical synthesis
发明人：CRONIN LEE; MANZANO SEBASTIÃ?N; ZALESSKIY SERGEY; KITSON PHILIP; WANG HSIN
权利人:UNIV GLASGOW COURT
摘要:The invention relates to a method and apparatus for performing and characterising a chemical synthesis, such as those performed with an automated chemical synthesis platform, including such that are portable platforms, the method comprising the steps of: performing a chemical synthesis in a chemical synthesiser; recording analytical data during the chemical synthesis, and developing a profile for the analytical data recorded over time; and comparing the profile for the chemical synthesis against a reference profile, which reference profile is the analytical data recorded over time for a reference chemical synthesis, wherein the chemical synthesis and the reference chemical synthesis share at least the same reagents and method steps for the same intended product, such as the chemical synthesis and the reference chemical synthesis sharing the same instruction set. The method and apparatus are for intended for use in replication of approved, chemical syntheses based on common reaction platforms.

专利号:WO-2024003151-A1
优先权日:2022-06-28
标 题:Chemical synthesis platform
发明人：CRONIN LEROY
权利人:UNIV GLASGOW COURT
摘要:The invention relates to a method for generating a database for chemical syntheses and a method for performing a chemical synthesis using a database. The method for generating a database comprises generating a series of instruction sets for a series of chemical syntheses from the literature, wherein each instruction set is a machine readable and executable universal language for a chemical synthesiser; assembling the series of instructions sets within a database, and making the instruction sets available for access and autonomous execution by a chemical synthesiser. The method for performing a chemical synthesis comprises accessing an instruction set from a database, providing the instruction set to a chemical synthesiser, and autonomously executing the instruction set on the chemical synthesiser thereby to perform the chemical synthesis. The invention makes use of a standardised and step-focussed syntax to describe the chemical syntheses, and a universal synthesis automation platform.

专利号:WO-2025121168-A1
优先权日:2023-12-08
标题:Gas reaction synthesis unit and gas reaction synthesis device
发明人：ICHIKAWA SHUICHI; ISHIHARA TAKUYA; ASANO MASATO
权利人:NGK INSULATORS LTD
摘要:A gas reaction synthesis unit 2 according to the present invention comprises: a honeycomb structure 20 having one or more honeycomb structure parts 24, each of which has an outer circumferential wall 240, and a partition wall 241 that is disposed inside the outer circumferential wall 240 and partitions and forms a plurality of cells 241a constituting flow channels extending from one end surface to the other end surface; and an induction heating coil 21 disposed on the outer circumference of the honeycomb structure 20. At least one of the one or more honeycomb structure parts 24 includes a conductor and/or a magnetic body 25.