CAS: 13063-04-2; 2,3-Dimethoxy-12-Methyl-[1,3]Dioxolo[4',5':4,5]Benzo[1,2-C]Phenanthridin-12-Ium Chloride

该化合物是一种化学化合物,属于异丙醇类,以其多种生物活动而闻名,其特点是分子结构,包括含氮的环环环,该化合物一般是晶状固体,在极溶剂中可溶解.氯化硝基苯因其潜在的治疗特性,包括抗癌和防炎影响,引起了对药理学的兴趣.其行动机制被认为涉及各种细胞路径的调控,尽管具体细节可能因使用而异.此外,它与许多藻类一样,可能对生物系统产生一系列影响,使其成为医药化学研究的课题.在与该化合物合作时,安全和处理预防措施至关重要,因为如果不加以妥善管理,可能会对健康造成危害.总的来说,氯化硝基苯是天然产品和药物开发领域的一个重要研究领域.

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CAS号548-31-2 (1,3)Benzodioxo... | CAS号105594-89-6 2-(3,4-dimethox... | CAS号13063-06-4 [1,3]Benzodioxo... | CAS号41303-45-1 7,8-二氢萘并[2,3-d]... | CAS号180411-09-0 6,6-dibromo-7,8... | CAS号180411-13-6 2-(2-bromo-6,7-... | CAS号18034-03-2 2,3-dimethoxy-[... | CAS号548-31-2 (1,3)Benzodioxo...

合成工艺路线路线简述

  • 合成目标产物 Nitidine Chloride 主要起始原料 (1,3)Benzodioxolo(5,6-C)Phenanthridin-13(12H)-One, 2,3-Dimethoxy-12-Methyl-
  • (文献来源)合成步骤主要原料 (1,3)Benzodioxolo(5,6-C)Phenanthridin-13(12H)-One, 2,3-Dimethoxy-12-Methyl-
📜2-碘-4,5-二甲氧基苯甲醛置于bis-Triphenylphosphine-Palladium(II) Chloride,Lithium Aluminium Tetrahydride,草酰氯,双氧水,三乙胺,N,N-二甲基甲酰胺,2,3-二氯-5,6-二氰基-1,4-苯醌,Potassium Hydroxide,Zinc(II) Chloride,锌体系中,用 四氢呋喃,甲醇,二氯甲烷,Aacetone,水,苯 用作溶剂,化学反应 29.33H,反应生成氯化两面针碱
参考文献:钯催化的串联反应来构建苯并[ C ^ ]菲啶:应用到苯并的全合成[ C ^ ]菲啶生物碱†
标题:钯催化的串联反应来构建苯并[ C ^ ]菲啶:应用到苯并的全合成[ C ^ ]菲啶生物碱†
摘要:通过钯催化氮杂双环烯烃与邻碘苯甲酸酯的开环偶联,然后串联环化,可实现苯并[ C ]菲啶的简洁高效合成.该策略已成功应用于苯并[ C ]菲啶生物碱的全合成,如血红碱,白屈菜红碱,尼替丁 和阿维辛.
Doi:10.1039/c0Ob01208D

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专利信息


专利号:CN-112851661-A
优先权日:2021-01-08
标 题:A method for the modular and diverse synthesis of triphenanthridine and protoberberine alkaloids

专利号:WO-2019076178-A1
优先权日:2017-10-18
标 题:Medical degradable polyurethane with adjustable degradation time and adjustable elongation at break
发明人：ZHANG WENFANG
权利人:COMSCAFFOLDS NANJING MEDICAL DEVICE CO LTD
摘要:The invention provides a medical degradable polyurethane with adjustable degradation time and adjustable elongation at break, a preparation method and application thereof, and can adjust the proportion of each component in the polyurethane synthesis process and select different chain extenders. Control the performance of PU in a wide range, such as PU degradation time, elongation at break, strength, lubricity and hydrophilicity, etc., can choose different properties of medical degradable polyurethane according to the needs of regenerative medicine and medical devices implanted in the body. .

专利号:CN-109369772-B
优先权日:2018-12-19
标 题 :Synthesis method and antitumor application of a kind of phenanthridine derivatives

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主要参考文献


1: Yuan Y, Zhu F, Pu Y, Wang D, Huang A, Hu X, Qin S, Sun X, Su Z, He C. Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation. Brain Behav Immun. 2015 Aug;48:287-300. doi: 10.1016/j.bbi.2015.04.008. doi: 10.1186/1475-2875-11-67.
3: Praveena C, Veeresham C. Multiple shoot regeneration and effect of sugars on growth and nitidine accumulation in shoot cultures of Toddalia asiatica. Pharmacogn Mag. 2014 Aug;10(Suppl 3):S480-6. doi: 10.4103/0973-1296.139777.
4: Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, Yi Z, Chen Y, Pang X, Liu M. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87. doi: 10.1158/1535-7163.MCT-11-0648. Chinese. doi: 10.1016/j.jpba.2014.11.051. doi: 10.1016/j.bios.2015.12.076. Chinese. doi: 10.1016/j.fct.2014.01.049. doi: 10.1016/j.fct.2013.07.062. doi: 10.1016/j.jep.2012.08.041. doi: 10.1093/chromsci/bmt003. doi: 10.3892/mmr.2016.4929. doi: 10.3892/mmr.2016.4827.

合成参考文献


摘要:National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program., JAN1986
参考文献:10.1021/np990005d
摘要:Nakanishi T, Suzuki M, Saimoto A, Kabasawa T. Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid. J Nat Prod. 1999 Jun;62(6):864–7. doi: 10.1021/np990005d.
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